The Bluetongue Disabled Infectious Single Animal (DISA) Vaccine Platform Based on Deletion NS3/NS3a Protein Is Safe and Protective in Cattle and Enables DIVA
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Rescue of DISA8
3.2. Vaccination Challenge Experiment in Cattle
3.2.1. DISA8 Is Safe and Protects against Bluetongue
3.2.2. DISA8 Protects against Viremia and Is Distinguishable by DIVA PCR Testing
3.2.3. The Immune Response against DISA8 Is Serotype Specific and Distinguishable
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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van Rijn, P.A.; Maris-Veldhuis, M.A.; van Gennip, R.G.P. The Bluetongue Disabled Infectious Single Animal (DISA) Vaccine Platform Based on Deletion NS3/NS3a Protein Is Safe and Protective in Cattle and Enables DIVA. Viruses 2021, 13, 857. https://doi.org/10.3390/v13050857
van Rijn PA, Maris-Veldhuis MA, van Gennip RGP. The Bluetongue Disabled Infectious Single Animal (DISA) Vaccine Platform Based on Deletion NS3/NS3a Protein Is Safe and Protective in Cattle and Enables DIVA. Viruses. 2021; 13(5):857. https://doi.org/10.3390/v13050857
Chicago/Turabian Stylevan Rijn, Piet A., Mieke A. Maris-Veldhuis, and René G. P. van Gennip. 2021. "The Bluetongue Disabled Infectious Single Animal (DISA) Vaccine Platform Based on Deletion NS3/NS3a Protein Is Safe and Protective in Cattle and Enables DIVA" Viruses 13, no. 5: 857. https://doi.org/10.3390/v13050857
APA Stylevan Rijn, P. A., Maris-Veldhuis, M. A., & van Gennip, R. G. P. (2021). The Bluetongue Disabled Infectious Single Animal (DISA) Vaccine Platform Based on Deletion NS3/NS3a Protein Is Safe and Protective in Cattle and Enables DIVA. Viruses, 13(5), 857. https://doi.org/10.3390/v13050857