Hearing Loss Caused by HCMV Infection through Regulating the Wnt and Notch Signaling Pathways

Huang, Sheng-Nan; Zhou, Yue-Peng; Jiang, Xuan; Yang, Bo; Cheng, Han; Luo, Min-Hua

doi:10.3390/v13040623

Open AccessReview

Hearing Loss Caused by HCMV Infection through Regulating the Wnt and Notch Signaling Pathways

by

Sheng-Nan Huang

^1,2,

Yue-Peng Zhou

^1,2,

Xuan Jiang

^1,3,

Bo Yang

^1,3,

Han Cheng

^4,* and

Min-Hua Luo

^1,2,4,*

¹

State Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology Wuhan Institute of Virology, Wuhan 430071, China

²

University of Chinese Academy of Sciences, Beijing 100049, China

³

Joint Center of Translational Precision Medicine, Guangzhou Institute of Pediatrics, Guangzhou Women and Children Medical Center, Guangzhou 510000, China

⁴

Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China

^*

Authors to whom correspondence should be addressed.

Viruses 2021, 13(4), 623; https://doi.org/10.3390/v13040623

Submission received: 16 February 2021 / Revised: 31 March 2021 / Accepted: 1 April 2021 / Published: 6 April 2021

(This article belongs to the Special Issue Viral Infection of Neural Stem Cells)

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Abstract

Hearing loss is one of the most prevalent sensory disabilities worldwide with huge social and economic burdens. The leading cause of sensorineural hearing loss (SNHL) in children is congenital cytomegalovirus (CMV) infection. Though the implementation of universal screening and early intervention such as antiviral or anti-inflammatory ameliorate the severity of CMV-associated diseases, direct and targeted therapeutics is still seriously lacking. The major hurdle for it is that the mechanism of CMV induced SNHL has not yet been well understood. In this review, we focus on the impact of CMV infection on the key players in inner ear development including the Wnt and Notch signaling pathways. Investigations on these interactions may gain new insights into viral pathogenesis and reveal novel targets for therapy.

Keywords: cytomegalovirus; congenital cytomegalovirus infection; sensorineural hearing loss; inner ear development; Wnt signaling pathway; Notch signaling pathway

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MDPI and ACS Style

Huang, S.-N.; Zhou, Y.-P.; Jiang, X.; Yang, B.; Cheng, H.; Luo, M.-H. Hearing Loss Caused by HCMV Infection through Regulating the Wnt and Notch Signaling Pathways. Viruses 2021, 13, 623. https://doi.org/10.3390/v13040623

AMA Style

Huang S-N, Zhou Y-P, Jiang X, Yang B, Cheng H, Luo M-H. Hearing Loss Caused by HCMV Infection through Regulating the Wnt and Notch Signaling Pathways. Viruses. 2021; 13(4):623. https://doi.org/10.3390/v13040623

Chicago/Turabian Style

Huang, Sheng-Nan, Yue-Peng Zhou, Xuan Jiang, Bo Yang, Han Cheng, and Min-Hua Luo. 2021. "Hearing Loss Caused by HCMV Infection through Regulating the Wnt and Notch Signaling Pathways" Viruses 13, no. 4: 623. https://doi.org/10.3390/v13040623

APA Style

Huang, S.-N., Zhou, Y.-P., Jiang, X., Yang, B., Cheng, H., & Luo, M.-H. (2021). Hearing Loss Caused by HCMV Infection through Regulating the Wnt and Notch Signaling Pathways. Viruses, 13(4), 623. https://doi.org/10.3390/v13040623

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Hearing Loss Caused by HCMV Infection through Regulating the Wnt and Notch Signaling Pathways

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