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Analysis of Different Types of Interferon-Associated Retinopathy in Patients with Chronic Hepatitis C Virus Infection Treated with Pegylated Interferon Plus Ribavirin

by 1,2, 2,3,4, 5, 6, 2,7,8,* and 2,8,9,10,*
1
Department of Ophthalmology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, Taiwan
2
School of Public Health, College of Public Health, Taipei Medical University, Taipei 110, Taiwan
3
Department of Family Medicine, Cardinal Tien Hospital, Fu Jen Catholic University, New Taipei City 231, Taiwan
4
School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan
5
Management Office for Health Data, China Medical University Hospital, Taichung 404, Taiwan
6
Department of Ophthalmology, Taipei Medical University Hospital, Taipei 110, Taiwan
7
Department of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
8
Master Program in Applied Molecular Epidemiology, College of Public Health, Taipei Medical University, Taipei 110, Taiwan
9
Department of Public Health, College of Public Health, China Medical University, Taichung 404, Taiwan
10
Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editor: Curt Hagedorn
Viruses 2021, 13(3), 475; https://doi.org/10.3390/v13030475
Received: 18 January 2021 / Revised: 24 February 2021 / Accepted: 11 March 2021 / Published: 14 March 2021
(This article belongs to the Section Viral Immunology, Vaccines, and Antivirals)
This retrospective cohort study aims to investigate interferon (IFN)-associated retinopathy incidence in patients with chronic hepatitis C virus (HCV) infection treated with pegylated interferon (PegIFN) plus ribavirin (RBV). We selected 1688 patients undergoing PegIFN/RBV therapy for HCV (HCV-treated cohort), 3376 patients not receiving HCV treatment (HCV-untreated cohort) and 16,880 controls without HCV (non-HCV cohort) from the Taiwan Longitudinal Health Insurance Database. The patients were frequency-matched by age, sex, and index date at a 1:2:10 ratio, and followed up until the end of 2013. Cox proportional hazard regression models were used to compare the incidences of any retinal vascular events, including subtypes, among the three cohorts. Compared with the non-HCV cohort, the HCV-treated cohort had a significantly increased risk of retinopathy (hazard ratio (HR) = 4.98, 95% confidence interval (CI): 2.02–12.3). The risk was particularly prominent for retinal hemorrhage (HR = 12.7, 95% CI: 3.78–42.9). When the HCV-untreated cohort was used as the reference, the aforementioned HRs increased to 9.02 (95% CI: 3.04–26.8) and 32.3 (95% CI: 3.94–265), respectively. This study suggested that PegIFN/RBV therapy significantly increased the risk of retinal hemorrhage but not retinal vascular occlusions in the HCV-treated cohort. View Full-Text
Keywords: hepatitis C virus; interferon-associated retinopathy; retinal hemorrhage; retrospective cohort study hepatitis C virus; interferon-associated retinopathy; retinal hemorrhage; retrospective cohort study
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MDPI and ACS Style

Wu, C.-M.; Su, F.-H.; Muo, C.-H.; Huang, J.-C.; Wu, M.-M.; Yeh, C.-C. Analysis of Different Types of Interferon-Associated Retinopathy in Patients with Chronic Hepatitis C Virus Infection Treated with Pegylated Interferon Plus Ribavirin. Viruses 2021, 13, 475. https://doi.org/10.3390/v13030475

AMA Style

Wu C-M, Su F-H, Muo C-H, Huang J-C, Wu M-M, Yeh C-C. Analysis of Different Types of Interferon-Associated Retinopathy in Patients with Chronic Hepatitis C Virus Infection Treated with Pegylated Interferon Plus Ribavirin. Viruses. 2021; 13(3):475. https://doi.org/10.3390/v13030475

Chicago/Turabian Style

Wu, Chia-Min, Fu-Hsiung Su, Chih-Hsin Muo, Jou-Chen Huang, Meei-Maan Wu, and Chih-Ching Yeh. 2021. "Analysis of Different Types of Interferon-Associated Retinopathy in Patients with Chronic Hepatitis C Virus Infection Treated with Pegylated Interferon Plus Ribavirin" Viruses 13, no. 3: 475. https://doi.org/10.3390/v13030475

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