Epstein–Barr Virus and Peri-Implantitis: A Systematic Review and Meta-Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. PECO Question (Population, Exposure, Comparison, Outcome)
2.2. Eligibility Criteria
- Cross-sectional studies and case–control studies.
- Written in English or Spanish.
- That evaluated the correlation between Epstein–Barr virus and the presence of peri-implantitis.
- Minimum sample of 20 implants.
- Peri-implantitis implants group (test) and healthy implants group (control).
- Peri-implant health diagnosis: radiological evaluation of bone loss and assessment of at least one clinical parameter.
- Systemically healthy subjects.
- No history of antibiotic therapy for at least three months.
2.3. Search Strategy
2.4. Study Selection
2.5. Data Extraction
2.6. Quality Assessment
2.7. Statistical Analysis
3. Results
3.1. Study Selection
3.2. Study Methods and Characteristics
3.3. Quality Assessment
3.4. EBV and Peri-Implantitis
3.5. Quantitative Analysis
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Author | Type of Study | N Implants | EBV in HI | EBV in PI | EBV in MI | Sample | |||
---|---|---|---|---|---|---|---|---|---|
Healthy Implants | Peri-Implantitis | Mucositis | Total | ||||||
Jankovic et al., 2011 [21] | Cross-sectional | 25 | 30 | 25 | 90 | 0/25 (0%) EBV-1; 2/25 (8%) EBV-2 | 11/30 (36.7%) EBV-1; 3/30 (10%) EBV-2 | 8/25 (32%) EBV-1; 1/25 (4%) EBV-2 | Subgingival plaque |
Verdugo et al., 2015 [35] | Cross-sectional | 23 | 23 | 0 | 46 | 1/23 (4.3%) | 9/23 (39.1%) | x | Subgingival plaque and saliva |
Kato et al., 2017 [19] | Case-control | 15 | 15 | 0 | 30 | 9/15 (60%) | 13/15 (86.7%) | x | Subgingival plaque |
Canullo et al., 2018 [27] | Cross-sectional | 113 | 77 | 0 | 190 | 23/113 (20.35%) | 15/77 (19.5%) | x | Subgingival plaque and internal implant connection |
Marques et al., 2018 [34] | Case-control | 21 | 21 | 0 | 42 | 2/21 (9.5%) | 4/21 (19%) | x | Saliva |
Total | 197 | 166 | 25 | 388 |
Selection | Comparability | Outcome/Exposure | |
---|---|---|---|
Jankovic et al., 2011 [21] | ⋆⋆⋆ | ⋆⋆ | ⋆⋆⋆ |
Verdugo et al., 2015 [35] | ⋆⋆⋆ | ⋆⋆⋆ | |
Kato et al., 2017 [19] | ⋆⋆ | ⋆ | ⋆⋆⋆ |
Canullo et al., 2018 [27] | ⋆⋆⋆ | ⋆⋆ | ⋆⋆⋆ |
Marques et al., 2018 [34] | ⋆⋆ | ⋆ | ⋆⋆ |
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Roca-Millan, E.; Domínguez-Mínger, J.; Schemel-Suárez, M.; Estrugo-Devesa, A.; Marí-Roig, A.; López-López, J. Epstein–Barr Virus and Peri-Implantitis: A Systematic Review and Meta-Analysis. Viruses 2021, 13, 250. https://doi.org/10.3390/v13020250
Roca-Millan E, Domínguez-Mínger J, Schemel-Suárez M, Estrugo-Devesa A, Marí-Roig A, López-López J. Epstein–Barr Virus and Peri-Implantitis: A Systematic Review and Meta-Analysis. Viruses. 2021; 13(2):250. https://doi.org/10.3390/v13020250
Chicago/Turabian StyleRoca-Millan, Elisabet, Judith Domínguez-Mínger, Mayra Schemel-Suárez, Albert Estrugo-Devesa, Antonio Marí-Roig, and José López-López. 2021. "Epstein–Barr Virus and Peri-Implantitis: A Systematic Review and Meta-Analysis" Viruses 13, no. 2: 250. https://doi.org/10.3390/v13020250
APA StyleRoca-Millan, E., Domínguez-Mínger, J., Schemel-Suárez, M., Estrugo-Devesa, A., Marí-Roig, A., & López-López, J. (2021). Epstein–Barr Virus and Peri-Implantitis: A Systematic Review and Meta-Analysis. Viruses, 13(2), 250. https://doi.org/10.3390/v13020250