Visualizing HIV-1 Capsid and Its Interactions with Antivirals and Host Factors
Abstract
:1. Introduction
2. Recent Advances Regarding Mature Capsid Structures
2.1. X-ray Crystallography
2.2. CryoEM/CryoET
2.3. NMR
3. Structures of the Capsid in Complex Host Cell Factors
3.1. CypA
3.2. Trim5α/TrimCyp
3.3. MxB
3.4. Nup358/Nup153
3.5. CPSF6
4. Structural Insights into the Effects of Small Molecules
4.1. Inositol Hexakisphosphate (IP6)
4.2. PF74 and GS-CA1/GS6207
5. Outlook
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Wilbourne, M.; Zhang, P. Visualizing HIV-1 Capsid and Its Interactions with Antivirals and Host Factors. Viruses 2021, 13, 246. https://doi.org/10.3390/v13020246
Wilbourne M, Zhang P. Visualizing HIV-1 Capsid and Its Interactions with Antivirals and Host Factors. Viruses. 2021; 13(2):246. https://doi.org/10.3390/v13020246
Chicago/Turabian StyleWilbourne, Morganne, and Peijun Zhang. 2021. "Visualizing HIV-1 Capsid and Its Interactions with Antivirals and Host Factors" Viruses 13, no. 2: 246. https://doi.org/10.3390/v13020246