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Article

Abnormal Blood Coagulation and Kidney Damage in Aged Hamsters Infected with Severe Acute Respiratory Syndrome Coronavirus 2

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Laboratory for Biologics Development, International Institute for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan
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Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan
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International Collaboration Unit, International Institute for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan
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Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan
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Laboratory of Agrobiomedical Science, Faculty of Agriculture, Hokkaido University, Sapporo 060-0818, Japan
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Department of Molecular Pathophysiology, School of Medicine, Shinshu University, Matsumoto 390-8621, Japan
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Division of Bioresources, International Institute for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan
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One Health Research Center, Hokkaido University, Sapporo 001-0020, Japan
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Authors to whom correspondence should be addressed.
Academic Editor: Andrew Davidson
Viruses 2021, 13(11), 2137; https://doi.org/10.3390/v13112137
Received: 29 September 2021 / Revised: 14 October 2021 / Accepted: 20 October 2021 / Published: 22 October 2021
(This article belongs to the Section SARS-CoV-2 and COVID-19)
Systemic symptoms have often been observed in patients with coronavirus disease 2019 (COVID-19) in addition to pneumonia, however, the details are still unclear due to the lack of an appropriate animal model. In this study, we investigated and compared blood coagulation abnormalities and tissue damage between male Syrian hamsters of 9 (young) and over 36 (aged) weeks old after intranasal infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite similar levels of viral replication and inflammatory responses in the lungs of both age groups, aged but not young hamsters showed significant prolongation of prothrombin time and prominent acute kidney damage. Moreover, aged hamsters demonstrated increased intravascular coagulation time-dependently in the lungs, suggesting that consumption of coagulation factors causes prothrombin time prolongation. Furthermore, proximal urinary tract damage and mesangial matrix expansion were observed in the kidneys of the aged hamsters at early and later disease stages, respectively. Given that the severity and mortality of COVID-19 are higher in elderly human patients, the effect of aging on pathogenesis needs to be understood and should be considered for the selection of animal models. We, thus, propose that the aged hamster is a good small animal model for COVID-19 research. View Full-Text
Keywords: COVID-19; animal model; aged Syrian hamster COVID-19; animal model; aged Syrian hamster
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MDPI and ACS Style

Ohno, M.; Sasaki, M.; Orba, Y.; Sekiya, T.; Masum, M.A.; Ichii, O.; Sawamura, T.; Kakino, A.; Suzuki, Y.; Kida, H.; Sawa, H.; Shingai, M. Abnormal Blood Coagulation and Kidney Damage in Aged Hamsters Infected with Severe Acute Respiratory Syndrome Coronavirus 2. Viruses 2021, 13, 2137. https://doi.org/10.3390/v13112137

AMA Style

Ohno M, Sasaki M, Orba Y, Sekiya T, Masum MA, Ichii O, Sawamura T, Kakino A, Suzuki Y, Kida H, Sawa H, Shingai M. Abnormal Blood Coagulation and Kidney Damage in Aged Hamsters Infected with Severe Acute Respiratory Syndrome Coronavirus 2. Viruses. 2021; 13(11):2137. https://doi.org/10.3390/v13112137

Chicago/Turabian Style

Ohno, Marumi, Michihito Sasaki, Yasuko Orba, Toshiki Sekiya, Md. A. Masum, Osamu Ichii, Tatsuya Sawamura, Akemi Kakino, Yasuhiko Suzuki, Hiroshi Kida, Hirofumi Sawa, and Masashi Shingai. 2021. "Abnormal Blood Coagulation and Kidney Damage in Aged Hamsters Infected with Severe Acute Respiratory Syndrome Coronavirus 2" Viruses 13, no. 11: 2137. https://doi.org/10.3390/v13112137

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