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Article

Ebola Virus Disease Survivors Show More Efficient Antibody Immunity than Vaccinees Despite Similar Levels of Circulating Immunoglobulins

1
Division of Infectious Diseases, 1st Department of Medicine, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany
2
Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
3
German Center for Infection Research, partner site Hamburg-Lübeck-Borstel-Riems, 20359 Hamburg, Germany
4
Clinical Psychology and Psychotherapy, Institute of Psychology, Faculty of Psychology and Human Movement Science, University of Hamburg, 20146 Hamburg, Germany
5
Ministry of Health Guinea, 2101 Conakry, Guinea
6
Université Gamal Abdel Nasser de Conakry, 2101 Conakry, Guinea
7
Research and Development Institute, National Infection Service, Public Health England, Porton Down, Salisbury, Wilts SP40JG, UK
*
Author to whom correspondence should be addressed.
Viruses 2020, 12(9), 915; https://doi.org/10.3390/v12090915
Received: 30 June 2020 / Revised: 6 August 2020 / Accepted: 18 August 2020 / Published: 20 August 2020
(This article belongs to the Collection Advances in Ebolavirus, Marburgvirus, and Cuevavirus Research)
The last seven years have seen the greatest surge of Ebola virus disease (EVD) cases in equatorial Africa, including the 2013–2016 epidemic in West Africa and the recent epidemics in the Democratic Republic of Congo (DRC). The vaccine clinical trials that took place in West Africa and the DRC, as well as follow-up studies in collaboration with EVD survivor communities, have for the first time allowed researchers to compare immune memory induced by natural infection and vaccination. These comparisons may be relevant to evaluate the putative effectiveness of vaccines and candidate medical countermeasures such as convalescent plasma transfer. In this study, we compared the long-term functionality of anti-EBOV glycoprotein (GP) antibodies from EVD survivors with that from volunteers who received the recombinant vesicular stomatitis virus vectored vaccine (rVSV-ZEBOV) during the Phase I clinical trial in Hamburg. Our study highlights important differences between EBOV vaccination and natural infection and provides a framework for comparison with other vaccine candidates. View Full-Text
Keywords: Ebola virus; VSV; vaccine; antibodies; immune memory Ebola virus; VSV; vaccine; antibodies; immune memory
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MDPI and ACS Style

Koch, T.; Rottstegge, M.; Ruibal, P.; Gomez-Medina, S.; Nelson, E.V.; Escudero-Pérez, B.; Pillny, M.; Ly, M.L.; Koundouno, F.R.; Bore, J.A.; Magassouba, N.; Dahlke, C.; Günther, S.; Carroll, M.W.; Addo, M.M.; Muñoz-Fontela, C. Ebola Virus Disease Survivors Show More Efficient Antibody Immunity than Vaccinees Despite Similar Levels of Circulating Immunoglobulins. Viruses 2020, 12, 915. https://doi.org/10.3390/v12090915

AMA Style

Koch T, Rottstegge M, Ruibal P, Gomez-Medina S, Nelson EV, Escudero-Pérez B, Pillny M, Ly ML, Koundouno FR, Bore JA, Magassouba N, Dahlke C, Günther S, Carroll MW, Addo MM, Muñoz-Fontela C. Ebola Virus Disease Survivors Show More Efficient Antibody Immunity than Vaccinees Despite Similar Levels of Circulating Immunoglobulins. Viruses. 2020; 12(9):915. https://doi.org/10.3390/v12090915

Chicago/Turabian Style

Koch, Till, Monika Rottstegge, Paula Ruibal, Sergio Gomez-Medina, Emily V. Nelson, Beatriz Escudero-Pérez, Matthias Pillny, My L. Ly, Fara R. Koundouno, Joseph A. Bore, N’Faly Magassouba, Christine Dahlke, Stephan Günther, Miles W. Carroll, Marylyn M. Addo, and César Muñoz-Fontela. 2020. "Ebola Virus Disease Survivors Show More Efficient Antibody Immunity than Vaccinees Despite Similar Levels of Circulating Immunoglobulins" Viruses 12, no. 9: 915. https://doi.org/10.3390/v12090915

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