Next Article in Journal
Impact of Lamivudine-Based Antiretroviral Treatment on Hepatitis B Viremia in HIV-Coinfected South Africans
Next Article in Special Issue
Role of Viruses in the Pathogenesis of Multiple Sclerosis
Previous Article in Journal
Year-Round Influenza a Virus Surveillance in Mallards (Anas platyrhynchos) Reveals Genetic Persistence During the Under-Sampled Spring Season
Previous Article in Special Issue
SETDB1-Mediated Silencing of Retroelements
Review

High-Throughput Sequencing is a Crucial Tool to Investigate the Contribution of Human Endogenous Retroviruses (HERVs) to Human Biology and Development

1
Laboratory of Molecular Virology, Department of Life and Environmental Sciences, University of Cagliari, 09042 Cagliari, Italy
2
Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, 09042 Cagliari, Italy
*
Author to whom correspondence should be addressed.
Viruses 2020, 12(6), 633; https://doi.org/10.3390/v12060633
Received: 24 April 2020 / Revised: 7 June 2020 / Accepted: 10 June 2020 / Published: 11 June 2020
(This article belongs to the Special Issue Endogenous Retroviruses in Development and Disease)
Human Endogenous retroviruses (HERVs) are remnants of ancient retroviral infections that represent a large fraction of our genome. Their transcriptional activity is finely regulated in early developmental stages and their expression is modulated in different cell types and tissues. Such activity has an impact on human physiology and pathology that is only partially understood up to date. Novel high-throughput sequencing tools have recently allowed for a great advancement in elucidating the various HERV expression patterns in different tissues as well as the mechanisms controlling their transcription, and overall, have helped in gaining better insights in an all-inclusive understanding of the impact of HERVs in biology of the host. View Full-Text
Keywords: HERVs; human genome; high-throughput sequencing; expression HERVs; human genome; high-throughput sequencing; expression
Show Figures

Figure 1

MDPI and ACS Style

Pisano, M.P.; Grandi, N.; Tramontano, E. High-Throughput Sequencing is a Crucial Tool to Investigate the Contribution of Human Endogenous Retroviruses (HERVs) to Human Biology and Development. Viruses 2020, 12, 633. https://doi.org/10.3390/v12060633

AMA Style

Pisano MP, Grandi N, Tramontano E. High-Throughput Sequencing is a Crucial Tool to Investigate the Contribution of Human Endogenous Retroviruses (HERVs) to Human Biology and Development. Viruses. 2020; 12(6):633. https://doi.org/10.3390/v12060633

Chicago/Turabian Style

Pisano, Maria P., Nicole Grandi, and Enzo Tramontano. 2020. "High-Throughput Sequencing is a Crucial Tool to Investigate the Contribution of Human Endogenous Retroviruses (HERVs) to Human Biology and Development" Viruses 12, no. 6: 633. https://doi.org/10.3390/v12060633

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop