Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoV
by
Jiabao Xu 1,†, Shizhe Zhao 1,†, 
Tieshan Teng 1
, Abualgasim Elgaili Abdalla 2, Wan Zhu 3, Longxiang Xie 1,*, Yunlong Wang 4,* and Xiangqian Guo 1,*
Jiabao Xu 1,†, Shizhe Zhao 1,†, Tieshan Teng 1, Abualgasim Elgaili Abdalla 2, Wan Zhu 3, Longxiang Xie 1,*, Yunlong Wang 4,* and Xiangqian Guo 1,*
1
Department of Preventive Medicine, Institute of Biomedical Informatics, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China
2
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 2014, Saudi Arabia
3
Department of Anesthesia, Stanford University, Stanford, CA 94305, USA
4
Henan Bioengineering Research Center, Zhengzhou 450046, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Viruses 2020, 12(2), 244; https://doi.org/10.3390/v12020244
Received: 4 February 2020 / Revised: 18 February 2020 / Accepted: 20 February 2020 / Published: 22 February 2020
(This article belongs to the Special Issue Pathogenesis of Human and Animal Coronaviruses)
After the outbreak of the severe acute respiratory syndrome (SARS) in the world in 2003, human coronaviruses (HCoVs) have been reported as pathogens that cause severe symptoms in respiratory tract infections. Recently, a new emerged HCoV isolated from the respiratory epithelium of unexplained pneumonia patients in the Wuhan seafood market caused a major disease outbreak and has been named the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This virus causes acute lung symptoms, leading to a condition that has been named as “coronavirus disease 2019” (COVID-19). The emergence of SARS-CoV-2 and of SARS-CoV caused widespread fear and concern and has threatened global health security. There are some similarities and differences in the epidemiology and clinical features between these two viruses and diseases that are caused by these viruses. The goal of this work is to systematically review and compare between SARS-CoV and SARS-CoV-2 in the context of their virus incubation, originations, diagnosis and treatment methods, genomic and proteomic sequences, and pathogenic mechanisms.
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Keywords:
coronaviruses; SARS-CoV-2; SARS-CoV; genomic comparison; proteomic comparison; pathogenic mechanism; clinical manifestations
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MDPI and ACS Style
Xu, J.; Zhao, S.; Teng, T.; Abdalla, A.E.; Zhu, W.; Xie, L.; Wang, Y.; Guo, X. Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoV. Viruses 2020, 12, 244.
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