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Open AccessCase Report

An Outbreak of a Respiratory Disorder at a Russian Swine Farm Associated with the Co-Circulation of PRRSV1 and PRRSV2

1
Federal State Budget Scientific Institution “Federal Scientific Center VIEV”, 109428 Moscow, Russia
2
Siberian Agrarian Group, 634009 Tomsk, Russia
3
Laboratory of Virology, Diagnostics and Prevention Research Institute for Human and Animal Diseases, 123098 Moscow, Russia
*
Author to whom correspondence should be addressed.
Viruses 2020, 12(10), 1169; https://doi.org/10.3390/v12101169
Received: 20 September 2020 / Revised: 6 October 2020 / Accepted: 11 October 2020 / Published: 15 October 2020
(This article belongs to the Special Issue Endemic and Emerging Swine Viruses)
We conducted a cross-sectional study to identify the major respiratory pathogen responsible for an outbreak of respiratory disease at a swine farm in West Siberia in 2019. We discovered that the peak of morbidity and mortality coincided with a high level of porcine reproductive and respiratory syndrome virus (PRRSV) 1 and 2-related viremia. Based on longer PRRSV2 viremia, the dominant role of PRRSV2 over PRRSV1 in the outbreak was assumed. Phylogenetic analysis revealed that the PRRSV1 strain belonged to sub-genotype 2—one of the predominant groups of genotype 1 PRRSVs in Russia. A partial open reading frame 7 sequence of the PRRSV2 isolate demonstrated a high identity with modified live vaccine-related strains from Denmark (93%) and wild-type VR2332 (92%). We identified the first instance of PRRSV1/PRRSV2 mixed infection in Russia. This finding indicates that further field investigations are needed to access PRRSV2 epidemiology in eastern Europe. View Full-Text
Keywords: PRRSV1; PRRSV2; PCV2; ORF7; cross-sectional; phylogenetic analysis; antibody detection PRRSV1; PRRSV2; PCV2; ORF7; cross-sectional; phylogenetic analysis; antibody detection
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Raev, S.; Yuzhakov, A.; Bulgakov, A.; Kostina, L.; Gerasianinov, A.; Verkhovsky, O.; Zaberezhny, A.; Aliper, T. An Outbreak of a Respiratory Disorder at a Russian Swine Farm Associated with the Co-Circulation of PRRSV1 and PRRSV2. Viruses 2020, 12, 1169.

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