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Open AccessReview

African Swine Fever: Disease Dynamics in Wild Boar Experimentally Infected with ASFV Isolates Belonging to Genotype I and II

1
Pathology Department, Animal and Plant Health Agency, APHA-Weybridge, Woodham Lane, New Haw, Addlestone KT15 3NB, UK
2
Department of Pathology and Wildlife Diseases, National Veterinary Institute (SVA), 751 89 Uppsala, Sweden
3
Biological Research Center (CIB-CSIC), Ramiro de Maeztu 9, 28040 Madrid, Spain
4
Virology Department, Animal and Plant Health Agency, APHA-Weybridge, Woodham Lane, New Haw, Addlestone KT15 3NB, UK
5
Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences (SLU), Box 7028, 750 07 Uppsala, Sweden
*
Author to whom correspondence should be addressed.
Viruses 2019, 11(9), 852; https://doi.org/10.3390/v11090852
Received: 12 August 2019 / Revised: 6 September 2019 / Accepted: 11 September 2019 / Published: 13 September 2019
(This article belongs to the Special Issue Porcine Viruses 2019)
After the re-introduction of African swine fever virus (ASFV) genotype II isolates into Georgia in 2007, the disease spread from Eastern to Western Europe and then jumped first up to Mongolian borders and later into China in August 2018, spreading out of control and reaching different countries of Southeast Asia in 2019. From the initial incursion, along with domestic pigs, wild boar displayed a high susceptibility to ASFV and disease development. The disease established self-sustaining cycles within the wild boar population, a key fact that helped its spread and that pointed to the wild boar population as a substantial reservoir in Europe and probably also in Asia, which may hinder eradication and serve as the source for further geographic expansion. The present review gathers the most relevant information available regarding infection dynamics, disease pathogenesis and immune response that experimental infections with different ASFV isolates belonging to genotype I and II in wild boar and feral pigs have generated. Knowledge gaps in areas such as disease pathogenesis and immune response highlights the importance of focusing future studies on unravelling the early mechanisms of virus-cell interaction and innate and/or adaptive immune responses, knowledge that will contribute to the development of efficacious treatments/vaccines against ASFV. View Full-Text
Keywords: African swine fever virus; genotype I and II; wild boar; experimental infection African swine fever virus; genotype I and II; wild boar; experimental infection
MDPI and ACS Style

Sánchez-Cordón, P.J.; Nunez, A.; Neimanis, A.; Wikström-Lassa, E.; Montoya, M.; Crooke, H.; Gavier-Widén, D. African Swine Fever: Disease Dynamics in Wild Boar Experimentally Infected with ASFV Isolates Belonging to Genotype I and II. Viruses 2019, 11, 852.

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