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Intestinal HAdV Infection: Tissue Specificity, Persistence, and Implications for Antiviral Therapy

Molecular Microbiology, Children’s Cancer Research Institute, Zimmermannplatz 10, 1090 Vienna, Austria
Viruses 2019, 11(9), 804; https://doi.org/10.3390/v11090804
Received: 2 July 2019 / Revised: 27 August 2019 / Accepted: 28 August 2019 / Published: 30 August 2019
(This article belongs to the Special Issue Adenovirus Pathogenesis)
Human adenovirus (HAdV) causes infections predominantly in early childhood and the tissue tropism of specific HAdV species determines the clinical manifestation, including infections of the gastrointestinal tract, respiratory tract, and keratoconjunctivitis. Why HAdV shows such a tropism has not yet been fully elucidated, but in the intestine different mechanisms for virus entry or resistence to immune modulatory factors have been described. Recently identified antiviral strategies by interferons provide evidence about the repression of E1A and maybe even promote HAdV persistence. The presence of HAdV in a persistent status in the gut is of importance in the setting of pediatric stem cell transplant recipients where HAdV detection in stool usually preceds clinical signs and severe infections are related to mortality. The reactivation of persistent intestinal HAdV infections in these patients needs further investigation also with regard to successful therapy options. In addition, several newly identified recombinant HAdV types have been isolated from stool samples, thus raising the question of possible recombination events in the gut. In this review, intestinal HAdV infections are discussed in relation to the tissue tropism, persistence, recombination, and new in-vitro models to enhance the knowledge about virus–host interactions and support the development of new treatment approaches. View Full-Text
Keywords: human adenovirus; intestinal infection; tissue tropism; recombination; persistence; antiviral mechanisms human adenovirus; intestinal infection; tissue tropism; recombination; persistence; antiviral mechanisms
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Kosulin, K. Intestinal HAdV Infection: Tissue Specificity, Persistence, and Implications for Antiviral Therapy. Viruses 2019, 11, 804.

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