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Pathogenesis of Hypervirulent Fowl Adenovirus Serotype 4: The Contributions of Viral and Host Factors

College of Animal Science and Veterinary Medicine, Henan Agricultural University, 95 Wenhua Road, Zhengzhou 450002, China
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Viruses 2019, 11(8), 741; https://doi.org/10.3390/v11080741
Received: 18 July 2019 / Revised: 9 August 2019 / Accepted: 10 August 2019 / Published: 12 August 2019
(This article belongs to the Special Issue Viral Evasion or Suppression of Host Immunity)
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PDF [228 KB, uploaded 12 August 2019]

Abstract

Since 2015, severe outbreaks of hepatitis-hydropericardium syndrome (HHS), caused by hypervirulent fowl adenovirus serotype 4 (FAdV-4), have emerged in several provinces in China, posing a great threat to poultry industry. So far, factors contributing to the pathogenesis of hypervirulent FAdV-4 have not been fully uncovered. Elucidation of the pathogenesis of FAdV-4 will facilitate the development of effective FAdV-4 vaccine candidates for the control of HHS and vaccine vector. The interaction between pathogen and host defense system determines the pathogenicity of the pathogen. Therefore, the present review highlights the knowledge of both viral and host factors contributing to the pathogenesis of hypervirulent FAdV-4 strains to facilitate the related further studies. View Full-Text
Keywords: hypervirulent FAdV-4; hepatitis-hydropericardium syndrome; pathogenesis; viral protein; host factor hypervirulent FAdV-4; hepatitis-hydropericardium syndrome; pathogenesis; viral protein; host factor
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Wang, Z.; Zhao, J. Pathogenesis of Hypervirulent Fowl Adenovirus Serotype 4: The Contributions of Viral and Host Factors. Viruses 2019, 11, 741.

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