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Identification of a Novel Equine Papillomavirus in Semen from a Thoroughbred Stallion with a Penile Lesion

1
Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life & Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia
2
Royal North Shore Hospital, Clinical Microbiology & Infectious Diseases, Reserve Road, St Leonards, NSW 2065, Australia
3
Vets & Veterinary Surgeons, Jerry Plains Veterinary Hospital, 10 Pagan Street, Jerry Plains, NSW 2330, Australia
*
Author to whom correspondence should be addressed.
Viruses 2019, 11(8), 713; https://doi.org/10.3390/v11080713
Received: 9 July 2019 / Revised: 30 July 2019 / Accepted: 1 August 2019 / Published: 4 August 2019
(This article belongs to the Special Issue Equine Viruses)
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Abstract

Papillomaviruses (PVs) have been identified in a wide range of animal species and are associated with a variety of disease syndromes including classical papillomatosis, aural plaques, and genital papillomas. In horses, 13 PVs have been described to date, falling into six genera. Using total RNA sequencing (meta-transcriptomics) we identified a novel equine papillomavirus in semen taken from a thoroughbred stallion suffering a genital lesion, which was confirmed by nested RT-PCR. We designate this novel virus Equus caballus papillomavirus 9 (EcPV9). The complete 7656 bp genome of EcPV9 exhibited similar characteristics to those of other horse papillomaviruses. Phylogenetic analysis based on concatenated E1-E2-L2-L1 amino acid sequences revealed that EcPV9 clustered with EcPV2, EcPV4, and EcPV5, although was distinct enough to represent a new viral species within the genus Dyoiotapapillomavirus (69.35%, 59.25%, and 58.00% nucleotide similarity to EcPV2, EcPV4, and EcPV5, respectively). In sum, we demonstrate the presence of a novel equine papillomavirus for which more detailed studies of disease association are merited. View Full-Text
Keywords: equine papillomaviruses; horse; genital wart; phylogeny; evolution equine papillomaviruses; horse; genital wart; phylogeny; evolution
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Li, C.-X.; Chang, W.-S.; Mitsakos, K.; Rodger, J.; Holmes, E.C.; Hudson, B.J. Identification of a Novel Equine Papillomavirus in Semen from a Thoroughbred Stallion with a Penile Lesion. Viruses 2019, 11, 713.

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