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Open AccessArticle

Phylogeography of Puumala orthohantavirus in Europe

1
CBGP, INRA, CIRAD, IRD, Montpellier SupAgro, Université Montpellier, 34000 Montpellier, France
2
MIVEGEC, Université de Montpellier, CNRS, IRD, 34394 Montpellier, France
3
LIRMM, Université de Montpellier, CNRS, 34095 Montpellier, France
4
ANSES, Virology Unit, 69007 Lyon, France
5
BIPAR-INRA Biologie Moléculaire et Immunologie Parasitaires et Fongiques, ENVA Maisons Alfort, 7 Avenue du Général de Gaulle, 94704 Maisons-Alfort CEDEX, France
6
Institut Pasteur, Antiviral Strategies Unit, Department of Virology, Paris, France & Institut Pasteur de Guinée, BP 4416 Conakry, Guinea
7
Department of Virology, University of Helsinki, 00014 Helsinki, Finland
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Viruses 2019, 11(8), 679; https://doi.org/10.3390/v11080679
Received: 29 May 2019 / Revised: 12 July 2019 / Accepted: 22 July 2019 / Published: 24 July 2019
(This article belongs to the Special Issue Hantaviruses)
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Abstract

Puumala virus is an RNA virus hosted by the bank vole (Myodes glareolus) and is today present in most European countries. Whilst it is generally accepted that hantaviruses have been tightly co-evolving with their hosts, Puumala virus (PUUV) evolutionary history is still controversial and so far has not been studied at the whole European level. This study attempts to reconstruct the phylogeographical spread of modern PUUV throughout Europe during the last postglacial period in the light of an upgraded dataset of complete PUUV small (S) segment sequences and by using most recent computational approaches. Taking advantage of the knowledge on the past migrations of its host, we identified at least three potential independent dispersal routes of PUUV during postglacial recolonization of Europe by the bank vole. From the Alpe-Adrian region (Balkan, Austria, and Hungary) to Western European countries (Germany, France, Belgium, and Netherland), and South Scandinavia. From the vicinity of Carpathian Mountains to the Baltic countries and to Poland, Russia, and Finland. The dissemination towards Denmark and North Scandinavia is more hypothetical and probably involved several independent streams from south and north Fennoscandia. View Full-Text
Keywords: puumala orthohantavirus; phylogeography; co-evolution; bank vole (myodes glareolus) puumala orthohantavirus; phylogeography; co-evolution; bank vole (myodes glareolus)
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Castel, G.; Chevenet, F.; Razzauti, M.; Murri, S.; Marianneau, P.; Cosson, J.-F.; Tordo, N.; Plyusnin, A. Phylogeography of Puumala orthohantavirus in Europe. Viruses 2019, 11, 679.

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