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Targeting Hemagglutinin: Approaches for Broad Protection against the Influenza A Virus

State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510006, China
Research Center of Agricultural of Dongguan City, Dongguan 523086, China
Firstline Biopharmaceuticals Corporation, 12,050 167th PL NE, Redmond, WA 98052, USA
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Viruses 2019, 11(5), 405;
Received: 10 April 2019 / Revised: 26 April 2019 / Accepted: 27 April 2019 / Published: 30 April 2019
(This article belongs to the Section Animal Viruses)
PDF [579 KB, uploaded 13 May 2019]


Influenza A viruses are dynamically epidemic and genetically diverse. Due to the antigenic drift and shift of the virus, seasonal vaccines are required to be reformulated annually to match with current circulating strains. However, the mismatch between vaccinal strains and circulating strains occurs frequently, resulting in the low efficacy of seasonal vaccines. Therefore, several “universal” vaccine candidates based on the structure and function of the hemagglutinin (HA) protein have been developed to meet the requirement of a broad protection against homo-/heterosubtypic challenges. Here, we review recent novel constructs and discuss several important findings regarding the broad protective efficacy of HA-based universal vaccines. View Full-Text
Keywords: influenza A virus; hemagglutinin; universal influenza vaccine influenza A virus; hemagglutinin; universal influenza vaccine

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Zhang, Y.; Xu, C.; Zhang, H.; Liu, G.D.; Xue, C.; Cao, Y. Targeting Hemagglutinin: Approaches for Broad Protection against the Influenza A Virus. Viruses 2019, 11, 405.

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