Histo-Blood Group Antigens in Children with Symptomatic Rotavirus Infection
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population and Specimens
2.2. Rotavirus Detection and Genotyping
2.3. Determination of Histo-Blood Group Antigens in Saliva
2.4. Genotypic Characterization of the FUT2 Gene (Secretor Status)
2.5. Statistical Analysis
3. Results
3.1. Study Population and Sample Collection
3.2. Rotavirus Genotypes
3.3. Secretor (FUT2) Status
3.4. Lewis and ABO Phenotypes
3.5. Association between HBGAs and Rotavirus Genotypes
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Patients | Controls a | p Value b | Odds Ratio c | Donors | p Value b | |||||
---|---|---|---|---|---|---|---|---|---|---|
(n = 133) (%) | (n = 50) (%) | 95% CI | (n = 283,399) (%) | |||||||
Blood Group | ||||||||||
O | 50 | (37.6) | 15 | (36.6) | 0.365 | * | 146,454 | (51.7) | 0.003 | |
A | 64 | (48.1) | 17 | (41.5) | 0.89 | (0.4–2) | 110,273 | (38.9) | ||
B | 10 | (7.5) | 7 | (17.1) | 2.31 | (0.7–7.2) | 19,054 | (6.7) | ||
AB | 9 | (6.8) | 2 | (4.9) | 0.78 | (0.1 - 3.6) | 7618 | (2.7) | ||
Secretor (FUT2) | ||||||||||
Secretor | 131 | (98.5) | 35 | (70) | 0.000 | * | NA | - | ||
Non-secretor | 2 | (1.5) | 15 | (30) | 25 | (6.7–100) | NA | |||
Lewis (FUT3) | ||||||||||
Negative | 8 | (6) | 3 | (6) | 1.000 | * | 31,090 | (11) | 0.091 | |
Positive | 125 | (94) | 47 | (94) | 0.97 | (0.26–4.84) | 252,309 | (89) | ||
Lewis A | ||||||||||
Negative | 73 | (54.9) | 15 | (30) | 0.005 | * | 225,219 | (79.5) | 0.000 | |
Positive | 60 | (45.1) | 35 | (70) | 2.81 | (1.42–5.78) | 56,180 | (20.5) | ||
Lewis B | ||||||||||
Negative | 10 | (7.5) | 18 | (36) | 0.000 | * | 88,784 | (31.3) | 0.000 | |
Positive | 123 | (92.5) | 32 | (64) | 0.15 | (0.06–0.35) | 194,615 | (68.7) | ||
Lewis A/B | ||||||||||
Le a– b– | 8 | (6) | 3 | (6) | 0.000 | * | 31,090 | (11) | 0.000 | |
Le a– b+ | 65 | (48.9) | 12 | (24) | 0.49 | (0.1–2.6) | 194,129 | (68.5) | ||
Le a+ b– | 2 | (1.5) | 15 | (30) | 16.47 | (2.6–169.7) | 57,694 | (20.3) | ||
Le a+ b+ | 58 | (43.6) | 20 | (40) | 0.9 | (0.2–4.6) | 486 | (0.2) |
G1P[8] | G2P[4] | G3P[8] | G4P[8] | G9P[8] | G12P[8] | p Value a | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
(n = 27) (%) | (n = 2) (%) | (n = 1) (%) | (n = 5) (%) | (n = 66) (%) | (n = 19) (%) | ||||||||
Blood Group | |||||||||||||
O | 10 | (37) | 0 | (0) | 0 | (0) | 2 | (40) | 24 | (36.4) | 9 | (47.4) | 0.826 |
A | 14 | (51.8) | 2 | (100) | 1 | (100) | 3 | (60) | 30 | (45.4) | 7 | (36.8) | |
B | 2 | (7.4) | 0 | (0) | 0 | (0) | 0 | (0) | 7 | (10.6) | 1 | (5.3) | |
AB | 1 | (3.7) | 0 | (0) | 0 | (0) | 0 | (0) | 5 | (7.6) | 2 | (10.5) | |
Secretor | |||||||||||||
Heterozygous | 16 | (59.3) | 2 | (100) | 1 | (100) | 3 | (60) | 44 | (66.7) | 8 | (42.1) | 0.265 |
Homozygous | 10 | (37) | 0 | (0) | 0 | (0) | 2 | (40) | 22 | (33.3) | 11 | (57.9) | |
Non-secretor | 1 | (3.7) | 0 | (0) | 0 | (0) | 0 | (0) | 0 | (0) | 0 | (0) | |
Lewis A / B | |||||||||||||
Le a– b– | 4 | (50) | 0 | (0) | 0 | (0) | 0 | (0) | 2 | (25) | 1 | (12.5) | 0.146 |
Le a– b+ | 15 | (23.1) | 1 | (1.5) | 0 | (0) | 3 | (4.6) | 30 | (46.1) | 11 | (16.9) | |
Le a+ b– | 1 | (50) | 0 | (0) | 0 | (0) | 0 | (0) | 0 | (0) | 0 | (0) | |
Le a+ b+ | 7 | (12.1) | 1 | (1.7) | 1 | (1.7) | 2 | (3.4) | 34 | (58.6) | 7 | (12.1) |
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Pérez-Ortín, R.; Vila-Vicent, S.; Carmona-Vicente, N.; Santiso-Bellón, C.; Rodríguez-Díaz, J.; Buesa, J. Histo-Blood Group Antigens in Children with Symptomatic Rotavirus Infection. Viruses 2019, 11, 339. https://doi.org/10.3390/v11040339
Pérez-Ortín R, Vila-Vicent S, Carmona-Vicente N, Santiso-Bellón C, Rodríguez-Díaz J, Buesa J. Histo-Blood Group Antigens in Children with Symptomatic Rotavirus Infection. Viruses. 2019; 11(4):339. https://doi.org/10.3390/v11040339
Chicago/Turabian StylePérez-Ortín, Raúl, Susana Vila-Vicent, Noelia Carmona-Vicente, Cristina Santiso-Bellón, Jesús Rodríguez-Díaz, and Javier Buesa. 2019. "Histo-Blood Group Antigens in Children with Symptomatic Rotavirus Infection" Viruses 11, no. 4: 339. https://doi.org/10.3390/v11040339