Next Article in Journal
The PB2 Polymerase Host Adaptation Substitutions Prime Avian Indonesia Sub Clade 2.1 H5N1 Viruses for Infecting Humans
Next Article in Special Issue
Discovery and Characterization of Novel Bat Coronavirus Lineages from Kazakhstan
Previous Article in Journal
Arthritogenic Alphavirus-Induced Immunopathology and Targeting Host Inflammation as A Therapeutic Strategy for Alphaviral Disease
Previous Article in Special Issue
Enhanced Autophagy Contributes to Reduced Viral Infection in Black Flying Fox Cells
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Viruses
Volume 11
Issue 3
10.3390/v11030291
viruses-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Differential Innate Immune Responses Elicited by Nipah Virus and Cedar Virus Correlate with Disparate In Vivo Pathogenesis in Hamsters

by
Tony Schountz
1,2,*,
Corey Campbell
1,2,
Kaitlyn Wagner
1,
Joel Rovnak
1,
Cynthia Martellaro
3,
Blair L DeBuysscher
3,4,
Heinz Feldmann
3 and
Joseph Prescott
3,5,*
1
Arthropod-borne and Infectious Diseases Laboratory, Colorado State University, Fort Collins, CO 80523, USA
2
Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
3
Laboratory of Virology, Rocky Mountain Laboratories, NIAID, Hamilton, MT 59840, USA
4
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
5
Center for Biological Threats and Special Pathogens, Robert Koch Institute, 13353 Berlin, Germany
*
Authors to whom correspondence should be addressed.
Viruses 2019, 11(3), 291; https://doi.org/10.3390/v11030291
Submission received: 25 February 2019 / Revised: 15 March 2019 / Accepted: 20 March 2019 / Published: 22 March 2019
(This article belongs to the Special Issue Viruses and Bats 2019)
Browse Figures
Versions Notes

Abstract

Syrian hamsters (Mesocricetus auratus) are a pathogenesis model for the Nipah virus (NiV), and we sought to determine if they are also susceptible to the Cedar virus (CedPV). Following intranasal inoculation with CedPV, virus replication occurred in the lungs and spleens of infected hamsters, a neutralizing antibody was produced in some hamsters within 8 days post-challenge, and no conspicuous signs of disease occurred. CedPV replicated to a similar magnitude as NiV-Bangladesh in type I IFN-deficient BHK-21 Syrian hamster fibroblasts but replicated 4 logs lower in type I IFN-competent primary Syrian hamster and human pulmonary endothelial cells, a principal target of henipaviruses. The coinfection of these cells with CedPV and NiV failed to rescue CedPV titers and did not diminish NiV titers, suggesting the replication machinery is virus-specific. Type I IFN response transcripts Ifna7, Ddx58, Stat1, Stat2, Ccl5, Cxcl10, Isg20, Irf7, and Iigp1 were all significantly elevated in CedPV-infected hamster endothelial cells, whereas Ifna7 and Iigp1 expression were significantly repressed during NiV infection. These results are consistent with the hypothesis that CedPV’s inability to counter the host type I IFN response may, in part, contribute to its lack of pathogenicity. Because NiV causes a fatal disease in Syrian hamsters with similarities to human disease, this model will provide valuable information about the pathogenic mechanisms of henipaviruses.
Keywords: Cedar virus; henipavirus; paramyxovirus; bat virus; Syrian hamster; antiviral response Cedar virus; henipavirus; paramyxovirus; bat virus; Syrian hamster; antiviral response

Share and Cite

MDPI and ACS Style

Schountz, T.; Campbell, C.; Wagner, K.; Rovnak, J.; Martellaro, C.; DeBuysscher, B.L.; Feldmann, H.; Prescott, J. Differential Innate Immune Responses Elicited by Nipah Virus and Cedar Virus Correlate with Disparate In Vivo Pathogenesis in Hamsters. Viruses 2019, 11, 291. https://doi.org/10.3390/v11030291

AMA Style

Schountz T, Campbell C, Wagner K, Rovnak J, Martellaro C, DeBuysscher BL, Feldmann H, Prescott J. Differential Innate Immune Responses Elicited by Nipah Virus and Cedar Virus Correlate with Disparate In Vivo Pathogenesis in Hamsters. Viruses. 2019; 11(3):291. https://doi.org/10.3390/v11030291

Chicago/Turabian Style

Schountz, Tony, Corey Campbell, Kaitlyn Wagner, Joel Rovnak, Cynthia Martellaro, Blair L DeBuysscher, Heinz Feldmann, and Joseph Prescott. 2019. "Differential Innate Immune Responses Elicited by Nipah Virus and Cedar Virus Correlate with Disparate In Vivo Pathogenesis in Hamsters" Viruses 11, no. 3: 291. https://doi.org/10.3390/v11030291

APA Style

Schountz, T., Campbell, C., Wagner, K., Rovnak, J., Martellaro, C., DeBuysscher, B. L., Feldmann, H., & Prescott, J. (2019). Differential Innate Immune Responses Elicited by Nipah Virus and Cedar Virus Correlate with Disparate In Vivo Pathogenesis in Hamsters. Viruses, 11(3), 291. https://doi.org/10.3390/v11030291

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop