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Identification of A Novel Picorna-Like Virus, Burpengary Virus, that is Negatively Associated with Chlamydial Disease in the Koala

1
Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia
2
Animal Research Centre, University of the Sunshine Coast, Sippy Downs, QLD 4556, Australia
*
Author to whom correspondence should be addressed.
Viruses 2019, 11(3), 211; https://doi.org/10.3390/v11030211
Received: 13 February 2019 / Revised: 28 February 2019 / Accepted: 1 March 2019 / Published: 2 March 2019
(This article belongs to the Section Animal Viruses)
Koalas (Phascolarctos cinereus) are native Australian marsupials whose populations are in decline from a range of threats. Infectious diseases caused by the bacterium Chlamydia pecorum and other pathogens are of particular concern. We analysed 26 poly-A selected RNA-sequencing libraries from a data set designed to study the immune response of koalas to ocular chlamydial infection. Using virus discovery techniques, we identified the coding-complete genome sequence of a novel picorna-like virus, denoted Burpengary virus, that was most common in south-east Queensland. Notably, abundance measurements of the virus across all 26 libraries revealed an inverse relationship between abundance and ocular disease in koalas, suggesting that the co-infection of Burpengary virus and Chlamydia pecorum is inhibited. View Full-Text
Keywords: virus discovery; Chlamydia pecorum; koala; picornavirus; phylogeny virus discovery; Chlamydia pecorum; koala; picornavirus; phylogeny
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MDPI and ACS Style

Harvey, E.; Madden, D.; Polkinghorne, A.; Holmes, E.C. Identification of A Novel Picorna-Like Virus, Burpengary Virus, that is Negatively Associated with Chlamydial Disease in the Koala. Viruses 2019, 11, 211. https://doi.org/10.3390/v11030211

AMA Style

Harvey E, Madden D, Polkinghorne A, Holmes EC. Identification of A Novel Picorna-Like Virus, Burpengary Virus, that is Negatively Associated with Chlamydial Disease in the Koala. Viruses. 2019; 11(3):211. https://doi.org/10.3390/v11030211

Chicago/Turabian Style

Harvey, Erin; Madden, Danielle; Polkinghorne, Adam; Holmes, Edward C. 2019. "Identification of A Novel Picorna-Like Virus, Burpengary Virus, that is Negatively Associated with Chlamydial Disease in the Koala" Viruses 11, no. 3: 211. https://doi.org/10.3390/v11030211

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