Shared Common Ancestry of Rodent Alphacoronaviruses Sampled Globally
AbstractThe recent discovery of novel alphacoronaviruses (alpha-CoVs) in European and Asian rodents revealed that rodent coronaviruses (CoVs) sampled worldwide formed a discrete phylogenetic group within this genus. To determine the evolutionary history of rodent CoVs in more detail, particularly the relative frequencies of virus-host co-divergence and cross-species transmission, we recovered longer fragments of CoV genomes from previously discovered European rodent alpha-CoVs using a combination of PCR and high-throughput sequencing. Accordingly, the full genome sequence was retrieved from the UK rat coronavirus, along with partial genome sequences from the UK field vole and Poland-resident bank vole CoVs, and a short conserved ORF1b fragment from the French rabbit CoV. Genome and phylogenetic analysis showed that despite their diverse geographic origins, all rodent alpha-CoVs formed a single monophyletic group and shared similar features, such as the same gene constellations, a recombinant beta-CoV spike gene, and similar core transcriptional regulatory sequences (TRS). These data suggest that all rodent alpha CoVs sampled so far originate from a single common ancestor, and that there has likely been a long-term association between alpha CoVs and rodents. Despite this likely antiquity, the phylogenetic pattern of the alpha-CoVs was also suggestive of relatively frequent host-jumping among the different rodent species. View Full-Text
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Tsoleridis, T.; Chappell, J.G.; Onianwa, O.; Marston, D.A.; Fooks, A.R.; Monchatre-Leroy, E.; Umhang, G.; Müller, M.A.; Drexler, J.F.; Drosten, C.; Tarlinton, R.E.; McClure, C.P.; Holmes, E.C.; Ball, J.K. Shared Common Ancestry of Rodent Alphacoronaviruses Sampled Globally. Viruses 2019, 11, 125.
Tsoleridis T, Chappell JG, Onianwa O, Marston DA, Fooks AR, Monchatre-Leroy E, Umhang G, Müller MA, Drexler JF, Drosten C, Tarlinton RE, McClure CP, Holmes EC, Ball JK. Shared Common Ancestry of Rodent Alphacoronaviruses Sampled Globally. Viruses. 2019; 11(2):125.Chicago/Turabian Style
Tsoleridis, Theocharis; Chappell, Joseph G.; Onianwa, Okechukwu; Marston, Denise A.; Fooks, Anthony R.; Monchatre-Leroy, Elodie; Umhang, Gérald; Müller, Marcel A.; Drexler, Jan F.; Drosten, Christian; Tarlinton, Rachael E.; McClure, Charles P.; Holmes, Edward C.; Ball, Jonathan K. 2019. "Shared Common Ancestry of Rodent Alphacoronaviruses Sampled Globally." Viruses 11, no. 2: 125.
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