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Open AccessArticle

Suggestive Serological Evidence of Infection with Shrew-Borne Imjin Virus (Hantaviridae) in Humans

1
State Key Laboratory of Virology, School of Health Sciences, Wuhan University, Wuhan 430071, China
2
School of Public Health, Shandong University, Jinan 250012, China
3
Qingdao Center for Disease Control and Prevention, Qingdao 266033, China
4
Zibo Center for Disease Control and Prevention, Zibo 255026, China
*
Author to whom correspondence should be addressed.
Authors contributed equally.
Viruses 2019, 11(12), 1128; https://doi.org/10.3390/v11121128
Received: 14 October 2019 / Revised: 24 November 2019 / Accepted: 2 December 2019 / Published: 6 December 2019
(This article belongs to the Special Issue Hantaviruses)
The pathogenicity of the shrew-borne Imjin virus (MJNV) is unknown. The objective of our study was to find serological evidence of MJNV infection in humans. Partial MJNV nucleocapsid protein (NP) was cloned and expressed as an antigen for double-antigen sandwich ELISA, IgM capture ELISA, and dot blot to detect MJNV specific antibodies in hemorrhagic fever with renal syndrome (HFRS) patients’ and healthy persons’ sera from endemic areas in China. The purified recombinant NP reacted with neither the 90 healthy individuals’ sera from non-endemic areas of MJNV nor the 100 antisera to HFRS-causing virus, indicating that the MJNV NP had no cross-reaction with normal human sera and HFRS-causing viral antibodies. As determined by screening ELISA and dot blot analysis, IgG antibodies against MJNV NP were detected in sera from two of 385 healthy individuals from MJNV-endemic areas, suggesting infection with MJNV or MJNV-like thottimvirus. Based on the suggestive evidence, healthcare workers should be alert to febrile diseases occurring among individuals with exposure to shrew-infested habitats. View Full-Text
Keywords: hantavirus; Imjin virus; shrew hantavirus; Imjin virus; shrew
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MDPI and ACS Style

Qi, R.; Sun, X.-F.; Qin, X.-R.; Wang, L.-J.; Zhao, M.; Jiang, F.; Wang, L.; Lei, X.-Y.; Liu, J.-W.; Yu, X.-J. Suggestive Serological Evidence of Infection with Shrew-Borne Imjin Virus (Hantaviridae) in Humans. Viruses 2019, 11, 1128.

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