Next Article in Journal
Genetic Characteristics and Pathogenicity Analysis in Chickens and Mice of Three H9N2 Avian Influenza Viruses
Next Article in Special Issue
Genetic Characterization and Molecular Evolution of Urban Seoul Virus in Southern China
Previous Article in Journal
Natural Infection of Aedes aegypti by Chikungunya and Dengue type 2 Virus in a Transition Area of North-Northeast Brazil
Previous Article in Special Issue
Spatiotemporal Dynamics of Hantavirus Cardiopulmonary Syndrome Transmission Risk in Brazil

Suggestive Serological Evidence of Infection with Shrew-Borne Imjin Virus (Hantaviridae) in Humans

State Key Laboratory of Virology, School of Health Sciences, Wuhan University, Wuhan 430071, China
School of Public Health, Shandong University, Jinan 250012, China
Qingdao Center for Disease Control and Prevention, Qingdao 266033, China
Zibo Center for Disease Control and Prevention, Zibo 255026, China
Author to whom correspondence should be addressed.
Authors contributed equally.
Viruses 2019, 11(12), 1128;
Received: 14 October 2019 / Revised: 24 November 2019 / Accepted: 2 December 2019 / Published: 6 December 2019
(This article belongs to the Special Issue Hantaviruses)
The pathogenicity of the shrew-borne Imjin virus (MJNV) is unknown. The objective of our study was to find serological evidence of MJNV infection in humans. Partial MJNV nucleocapsid protein (NP) was cloned and expressed as an antigen for double-antigen sandwich ELISA, IgM capture ELISA, and dot blot to detect MJNV specific antibodies in hemorrhagic fever with renal syndrome (HFRS) patients’ and healthy persons’ sera from endemic areas in China. The purified recombinant NP reacted with neither the 90 healthy individuals’ sera from non-endemic areas of MJNV nor the 100 antisera to HFRS-causing virus, indicating that the MJNV NP had no cross-reaction with normal human sera and HFRS-causing viral antibodies. As determined by screening ELISA and dot blot analysis, IgG antibodies against MJNV NP were detected in sera from two of 385 healthy individuals from MJNV-endemic areas, suggesting infection with MJNV or MJNV-like thottimvirus. Based on the suggestive evidence, healthcare workers should be alert to febrile diseases occurring among individuals with exposure to shrew-infested habitats. View Full-Text
Keywords: hantavirus; Imjin virus; shrew hantavirus; Imjin virus; shrew
Show Figures

Figure 1

MDPI and ACS Style

Qi, R.; Sun, X.-F.; Qin, X.-R.; Wang, L.-J.; Zhao, M.; Jiang, F.; Wang, L.; Lei, X.-Y.; Liu, J.-W.; Yu, X.-J. Suggestive Serological Evidence of Infection with Shrew-Borne Imjin Virus (Hantaviridae) in Humans. Viruses 2019, 11, 1128.

AMA Style

Qi R, Sun X-F, Qin X-R, Wang L-J, Zhao M, Jiang F, Wang L, Lei X-Y, Liu J-W, Yu X-J. Suggestive Serological Evidence of Infection with Shrew-Borne Imjin Virus (Hantaviridae) in Humans. Viruses. 2019; 11(12):1128.

Chicago/Turabian Style

Qi, Rui, Xi-Feng Sun, Xiang-Rong Qin, Li-Jun Wang, Min Zhao, Fachun Jiang, Ling Wang, Xiao-Ying Lei, Jian-Wei Liu, and Xue-Jie Yu. 2019. "Suggestive Serological Evidence of Infection with Shrew-Borne Imjin Virus (Hantaviridae) in Humans" Viruses 11, no. 12: 1128.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop