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The C4 Protein from Tomato Yellow Leaf Curl Virus Can Broadly Interact with Plant Receptor-Like Kinases

1
Shanghai Center for Plant Stress Biology, Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai 201602, China
2
University of the Chinese Academy of Sciences, Beijing 100049, China
*
Author to whom correspondence should be addressed.
Present address: Department of Cell Biology, Centre for Organismal Studies Heidelberg, Heidelberg University, 69120 Heidelberg, Germany.
Present address: Instituto de Hortofruticultura Subtropical y Mediterránea “La Mayora” (IHSM-UMA-CSIC), Area de Genética, Facultad de Ciencias, Universidad de Málaga, Campus de Teatinos s/n, E-29071 Málaga, Spain.
Viruses 2019, 11(11), 1009; https://doi.org/10.3390/v11111009
Received: 12 September 2019 / Revised: 3 October 2019 / Accepted: 11 October 2019 / Published: 31 October 2019
(This article belongs to the Section Viruses of Plants, Fungi and Protozoa)
Plant receptor-like kinases (RLKs) exert an essential function in the transduction of signals from the cell exterior to the cell interior, acting as important regulators of plant development and responses to environmental conditions. A growing body of evidence suggests that RLKs may play relevant roles in plant-virus interactions, although the details and diversity of effects and underlying mechanisms remain elusive. The C4 protein from different geminiviruses has been found to interact with RLKs in the CLAVATA 1 (CLV1) clade. However, whether C4 can interact with RLKs in other subfamilies and, if so, what the biological impact of such interactions might be, is currently unknown. In this work, we explore the interaction landscape of C4 from the geminivirus Tomato yellow leaf curl virus within the Arabidopsis RLK family. Our results show that C4 can interact with RLKs from different subfamilies including, but not restricted to, members of the CLV1 clade. Functional analyses of the interaction of C4 with two well-characterized RLKs, FLAGELLIN SENSING 2 (FLS2) and BRASSINOSTEROID INSENSITIVE 1 (BRI1), indicate that C4 might affect some, but not all, RLK-derived outputs. The results presented here offer novel insight on the interface between RLK signaling and the infection by geminiviruses, and point at C4 as a potential broad manipulator of RLK-mediated signaling. View Full-Text
Keywords: geminivirus; C4; TYLCV; RLK; CLV1; FLS2; BRI1; BRL3; NIK1; PSKR1 geminivirus; C4; TYLCV; RLK; CLV1; FLS2; BRI1; BRL3; NIK1; PSKR1
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MDPI and ACS Style

Garnelo Gómez, B.; Zhang, D.; Rosas-Díaz, T.; Wei, Y.; Macho, A.P.; Lozano-Durán, R. The C4 Protein from Tomato Yellow Leaf Curl Virus Can Broadly Interact with Plant Receptor-Like Kinases. Viruses 2019, 11, 1009.

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