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Viral Delivery Systems for CRISPR

1
Edward S. Harkness Eye Institute, New York-Presbyterian Hospital, New York, NY 10032, USA
2
Jonas Children’s Vision Care and Bernard & Shirlee Brown Glaucoma Laboratory, Columbia University, New York, NY 10032, USA
3
Omics Laboratory, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA 94301, USA
4
Veterans Affairs Palo Alto Health Care, Palo Alto, CA 94301, USA
5
Department of Pathology & Cell Biology, Stem Cell Initiative (CSCI), Institute of Human Nutrition, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
*
Author to whom correspondence should be addressed.
Viruses 2019, 11(1), 28; https://doi.org/10.3390/v11010028
Received: 17 December 2018 / Revised: 31 December 2018 / Accepted: 1 January 2019 / Published: 4 January 2019
(This article belongs to the Special Issue Applications of CRISPR Technology in Virology 2018)
The frontiers of precision medicine have been revolutionized by the development of Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPR)/Cas9 as an editing tool. CRISPR/Cas9 has been used to develop animal models, understand disease mechanisms, and validate treatment targets. In addition, it is regarded as an effective tool for genome surgery when combined with viral delivery vectors. In this article, we will explore the various viral mechanisms for delivering CRISPR/Cas9 into tissues and cells, as well as the benefits and drawbacks of each method. We will also review the history and recent development of CRISPR and viral vectors and discuss their applications as a powerful tool in furthering our exploration of disease mechanisms and therapies. View Full-Text
Keywords: CRISPR; viral vectors; gene therapy; animal models; gene editing CRISPR; viral vectors; gene therapy; animal models; gene editing
MDPI and ACS Style

Xu, C.L.; Ruan, M.Z.C.; Mahajan, V.B.; Tsang, S.H. Viral Delivery Systems for CRISPR. Viruses 2019, 11, 28. https://doi.org/10.3390/v11010028

AMA Style

Xu CL, Ruan MZC, Mahajan VB, Tsang SH. Viral Delivery Systems for CRISPR. Viruses. 2019; 11(1):28. https://doi.org/10.3390/v11010028

Chicago/Turabian Style

Xu, Christine L.; Ruan, Merry Z.C.; Mahajan, Vinit B.; Tsang, Stephen H. 2019. "Viral Delivery Systems for CRISPR" Viruses 11, no. 1: 28. https://doi.org/10.3390/v11010028

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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