Next Article in Journal
The NS Segment of H1N1pdm09 Enhances H5N1 Pathogenicity in a Mouse Model of Influenza Virus Infections
Next Article in Special Issue
Pospiviroid Infection of Tomato Regulates the Expression of Genes Involved in Flower and Fruit Development
Previous Article in Journal
Acute Phase Protein Levels as An Auxiliary Tool in Diagnosing Viral Diseases in Ruminants—A Review
Previous Article in Special Issue
Time-Course Microarray Analysis Reveals Differences between Transcriptional Changes in Tomato Leaves Triggered by Mild and Severe Variants of Potato Spindle Tuber Viroid
Open AccessReview

Potato Spindle Tuber Viroid RNA-Templated Transcription: Factors and Regulation

Department of Biological Sciences, Mississippi State University, Starkville, MS 39762, USA
Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45237, USA
College of Medicine, Ohio State University, Columbus, OH 43210, USA
Author to whom correspondence should be addressed.
The author has contributed equally as co-first authors of this work.
Viruses 2018, 10(9), 503;
Received: 27 August 2018 / Revised: 10 September 2018 / Accepted: 15 September 2018 / Published: 17 September 2018
(This article belongs to the Special Issue Viroid-2018: International Conference on Viroids and Viroid-Like RNAs)
Viroids are circular noncoding RNAs that infect plants. Without encoding any protein, these noncoding RNAs contain the necessary genetic information for propagation in hosts. Nuclear-replicating viroids employ DNA-dependent RNA polymerase II (Pol II) for replication, a process that makes a DNA-dependent enzyme recognize RNA templates. Recently, a splicing variant of transcription factor IIIA (TFIIIA-7ZF) was identified as essential for Pol II to replicate potato spindle tuber viroid (PSTVd). The expression of TFIIIA-7ZF, particularly the splicing event, is regulated by a ribosomal protein (RPL5). PSTVd modulates its expression through a direct interaction with RPL5 resulting in optimized expression of TFIIIA-7ZF. This review summarizes the recent discoveries of host factors and regulatory mechanisms underlying PSTVd-templated transcription processes and raises new questions that may help future exploration in this direction. In addition, it briefly compares the machinery and the regulatory mechanism for PSTVd with the replication/transcription system of human hepatitis delta virus. View Full-Text
Keywords: viroid replication; hepatitis delta virus; TFIIIA; RPL5; Pol II; alternative splicing; HDAg viroid replication; hepatitis delta virus; TFIIIA; RPL5; Pol II; alternative splicing; HDAg
Show Figures

Graphical abstract

MDPI and ACS Style

Dissanayaka Mudiyanselage, S.D.; Qu, J.; Tian, N.; Jiang, J.; Wang, Y. Potato Spindle Tuber Viroid RNA-Templated Transcription: Factors and Regulation. Viruses 2018, 10, 503.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop