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Viruses 2018, 10(5), 249; https://doi.org/10.3390/v10050249

Thiol-Activated Hydrogen Sulfide Donors Antiviral and Anti-Inflammatory Activity in Respiratory Syncytial Virus Infection

1
Department of Pediatrics, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA
2
Department of Chemistry, Washington State University, Pullman, WA 99164, USA
3
Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA
These authors have equally contributed to the work.
*
Author to whom correspondence should be addressed.
Received: 12 March 2018 / Revised: 8 May 2018 / Accepted: 8 May 2018 / Published: 10 May 2018
(This article belongs to the Section Antivirals & Vaccines)
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Abstract

We have recently shown that endogenous hydrogen sulfide (H2S), an important cellular gaseous mediator, exerts an antiviral and anti-inflammatory activity in vitro and in vivo, and that exogenous H2S delivered via the synthetic H2S-releasing compound GYY4137 also has similar properties. In this study, we sought to extend our findings to a novel class of H2S donors, thiol-activated gem-dithiol-based (TAGDDs). In an in vitro model of human respiratory syncytial virus (RSV) infection, TAGDD-1 treatment significantly reduced viral replication, even when added up to six hours after infection. Using a mouse model of RSV infection, intranasal delivery of TAGDD-1 to infected mice significantly reduced viral replication and lung inflammation, markedly improving clinical disease parameters and pulmonary dysfunction, compared to vehicle treated controls. Overall our results indicate that this novel synthetic class of H2S-releasing compounds exerts antiviral and anti-inflammatory activity in the context of RSV infection and represents a potential novel pharmacological approach to ameliorate viral-induced lung disease. View Full-Text
Keywords: respiratory syncytial virus; hydrogen sulfide donor; airway inflammation; mouse model respiratory syncytial virus; hydrogen sulfide donor; airway inflammation; mouse model
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Bazhanov, N.; Ivanciuc, T.; Wu, H.; Garofalo, M.; Kang, J.; Xian, M.; Casola, A. Thiol-Activated Hydrogen Sulfide Donors Antiviral and Anti-Inflammatory Activity in Respiratory Syncytial Virus Infection. Viruses 2018, 10, 249.

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