Interferon Independent Non-Canonical STAT Activation and Virus Induced Inflammation
1
Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, China
2
Molecular Virology Laboratory, VA-MD College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland, College Park, MD 20742, USA
*
Authors to whom correspondence should be addressed.
Viruses 2018, 10(4), 196; https://doi.org/10.3390/v10040196
Received: 28 February 2018 / Revised: 7 April 2018 / Accepted: 11 April 2018 / Published: 14 April 2018
(This article belongs to the Special Issue Viruses and Inflammation)
Interferons (IFNs) are a group of secreted proteins that play critical roles in antiviral immunity, antitumor activity, activation of cytotoxic T cells, and modulation of host immune responses. IFNs are cytokines, and bind receptors on cell surfaces to trigger signal transduction. The major signaling pathway activated by IFNs is the JAK/STAT (Janus kinase/signal transducer and activator of transcription) pathway, a complex pathway involved in both viral and host survival strategies. On the one hand, viruses have evolved strategies to escape from antiviral host defenses evoked by IFN-activated JAK/STAT signaling. On the other hand, viruses have also evolved to exploit the JAK/STAT pathway to evoke activation of certain STATs that somehow promote viral pathogenesis. In this review, recent progress in our understanding of the virus-induced IFN-independent STAT signaling and its potential roles in viral induced inflammation and pathogenesis are summarized in detail, and perspectives are provided.
View Full-Text
Keywords:
Interferons; JAK/STAT signaling; non-canonical STAT activation; viral antagonism; inflammation
▼
Show Figures
Figure 1
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Nan, Y.; Wu, C.; Zhang, Y.-J. Interferon Independent Non-Canonical STAT Activation and Virus Induced Inflammation. Viruses 2018, 10, 196. https://doi.org/10.3390/v10040196
AMA Style
Nan Y, Wu C, Zhang Y-J. Interferon Independent Non-Canonical STAT Activation and Virus Induced Inflammation. Viruses. 2018; 10(4):196. https://doi.org/10.3390/v10040196
Chicago/Turabian StyleNan, Yuchen; Wu, Chunyan; Zhang, Yan-Jin. 2018. "Interferon Independent Non-Canonical STAT Activation and Virus Induced Inflammation" Viruses 10, no. 4: 196. https://doi.org/10.3390/v10040196
Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
Search more from Scilit
