Next Article in Journal
Rapid Viral Diagnosis of Orthopoxviruses by Electron Microscopy: Optional or a Must?
Next Article in Special Issue
Honey Bee Antiviral Immune Barriers as Affected by Multiple Stress Factors: A Novel Paradigm to Interpret Colony Health Decline and Collapse
Previous Article in Journal
The Host Factor Early Growth Response Gene (EGR-1) Regulates Vaccinia virus Infectivity during Infection of Starved Mouse Cells
Previous Article in Special Issue
Antiviral Defense and Innate Immune Memory in the Oyster
Open AccessReview

Conflict in the Intracellular Lives of Endosymbionts and Viruses: A Mechanistic Look at Wolbachia-Mediated Pathogen-blocking

Department of Biology, Indiana University, Bloomington, IN 47405, USA
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Viruses 2018, 10(4), 141; https://doi.org/10.3390/v10040141
Received: 28 February 2018 / Revised: 14 March 2018 / Accepted: 20 March 2018 / Published: 21 March 2018
(This article belongs to the Special Issue Antiviral Defense in Invertebrates)
At the forefront of vector control efforts are strategies that leverage host-microbe associations to reduce vectorial capacity. The most promising of these efforts employs Wolbachia, a maternally transmitted endosymbiotic bacterium naturally found in 40% of insects. Wolbachia can spread through a population of insects while simultaneously inhibiting the replication of viruses within its host. Despite successes in using Wolbachia-transfected mosquitoes to limit dengue, Zika, and chikungunya transmission, the mechanisms behind pathogen-blocking have not been fully characterized. Firstly, we discuss how Wolbachia and viruses both require specific host-derived structures, compounds, and processes to initiate and maintain infection. There is significant overlap in these requirements, and infection with either microbe often manifests as cellular stress, which may be a key component of Wolbachia’s anti-viral effect. Secondly, we discuss the current understanding of pathogen-blocking through this lens of cellular stress and develop a comprehensive view of how the lives of Wolbachia and viruses are fundamentally in conflict with each other. A thorough understanding of the genetic and cellular determinants of pathogen-blocking will significantly enhance the ability of vector control programs to deploy and maintain effective Wolbachia-mediated control measures. View Full-Text
Keywords: vector control; antiviral; symbiosis; endosymbiont; arbovirus; Drosophila; Aedes vector control; antiviral; symbiosis; endosymbiont; arbovirus; Drosophila; Aedes
Show Figures

Figure 1

MDPI and ACS Style

Lindsey, A.R.I.; Bhattacharya, T.; Newton, I.L.G.; Hardy, R.W. Conflict in the Intracellular Lives of Endosymbionts and Viruses: A Mechanistic Look at Wolbachia-Mediated Pathogen-blocking. Viruses 2018, 10, 141.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop