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Open AccessReview

Suppression of Type I Interferon Signaling by Flavivirus NS5

1
Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA
2
Graduate Program in Cell, Molecular and Developmental Biology, University of California, Riverside, Riverside, CA 92521, USA
3
Department of Biochemistry, University of California, Riverside, Riverside, CA 92521, USA
*
Authors to whom correspondence should be addressed.
Viruses 2018, 10(12), 712; https://doi.org/10.3390/v10120712
Received: 21 November 2018 / Revised: 8 December 2018 / Accepted: 9 December 2018 / Published: 14 December 2018
(This article belongs to the Special Issue New Advances on Zika Virus Research)
Type I interferon (IFN-I) is the first line of mammalian host defense against viral infection. To counteract this, the flaviviruses, like other viruses, have encoded a variety of antagonists, and use a multi-layered molecular defense strategy to establish their infections. Among the most potent antagonists is non-structural protein 5 (NS5), which has been shown for all disease-causing flaviviruses to target different steps and players of the type I IFN signaling pathway. Here, we summarize the type I IFN antagonist mechanisms used by flaviviruses with a focus on the role of NS5 in regulating one key regulator of type I IFN, signal transducer and activator of transcription 2 (STAT2). View Full-Text
Keywords: flavivirus; ZIKV; NS5; type I IFN antagonist flavivirus; ZIKV; NS5; type I IFN antagonist
MDPI and ACS Style

Thurmond, S.; Wang, B.; Song, J.; Hai, R. Suppression of Type I Interferon Signaling by Flavivirus NS5. Viruses 2018, 10, 712.

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