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Viruses 2018, 10(10), 541;

Fetal Brain Infection Is Not a Unique Characteristic of Brazilian Zika Viruses

Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia 4072, Australia
Inflammation Biology Group, QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia
Department of Virology I, National Institute of Infectious Diseases, Tokyo 162-8640, Japan
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 29 August 2018 / Revised: 20 September 2018 / Accepted: 30 September 2018 / Published: 3 October 2018
(This article belongs to the Special Issue New Advances on Zika Virus Research)
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The recent emergence of Zika virus (ZIKV) in Brazil was associated with an increased number of fetal brain infections that resulted in a spectrum of congenital neurological complications known as congenital Zika syndrome (CZS). Herein, we generated de novo from sequence data an early Asian lineage ZIKV isolate (ZIKV-MY; Malaysia, 1966) not associated with microcephaly and compared the in vitro replication kinetics and fetal brain infection in interferon α/β receptor 1 knockout (IFNAR1−/−) dams of this isolate and of a Brazilian isolate (ZIKV-Natal; Natal, 2015) unequivocally associated with microcephaly. The replication efficiencies of ZIKV-MY and ZIKV-Natal in A549 and Vero cells were similar, while ZIKV-MY replicated more efficiently in wild-type (WT) and IFNAR−/− mouse embryonic fibroblasts. Viremias in IFNAR1−/− dams were similar after infection with ZIKV-MY or ZIKV-Natal, and importantly, infection of fetal brains was also not significantly different. Thus, fetal brain infection does not appear to be a unique feature of Brazilian ZIKV isolates. View Full-Text
Keywords: Zika virus; pregnancy; fetal infection; congenital Zika syndrome; Asian lineage Zika virus; pregnancy; fetal infection; congenital Zika syndrome; Asian lineage

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Setoh, Y.X.; Peng, N.Y.; Nakayama, E.; Amarilla, A.A.; Prow, N.A.; Suhrbier, A.; Khromykh, A.A. Fetal Brain Infection Is Not a Unique Characteristic of Brazilian Zika Viruses. Viruses 2018, 10, 541.

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