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Viruses 2018, 10(10), 541; https://doi.org/10.3390/v10100541

Fetal Brain Infection Is Not a Unique Characteristic of Brazilian Zika Viruses

1
Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia 4072, Australia
2
Inflammation Biology Group, QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia
3
Department of Virology I, National Institute of Infectious Diseases, Tokyo 162-8640, Japan
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 29 August 2018 / Revised: 20 September 2018 / Accepted: 30 September 2018 / Published: 3 October 2018
(This article belongs to the Special Issue New Advances on Zika Virus Research)
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Abstract

The recent emergence of Zika virus (ZIKV) in Brazil was associated with an increased number of fetal brain infections that resulted in a spectrum of congenital neurological complications known as congenital Zika syndrome (CZS). Herein, we generated de novo from sequence data an early Asian lineage ZIKV isolate (ZIKV-MY; Malaysia, 1966) not associated with microcephaly and compared the in vitro replication kinetics and fetal brain infection in interferon α/β receptor 1 knockout (IFNAR1−/−) dams of this isolate and of a Brazilian isolate (ZIKV-Natal; Natal, 2015) unequivocally associated with microcephaly. The replication efficiencies of ZIKV-MY and ZIKV-Natal in A549 and Vero cells were similar, while ZIKV-MY replicated more efficiently in wild-type (WT) and IFNAR−/− mouse embryonic fibroblasts. Viremias in IFNAR1−/− dams were similar after infection with ZIKV-MY or ZIKV-Natal, and importantly, infection of fetal brains was also not significantly different. Thus, fetal brain infection does not appear to be a unique feature of Brazilian ZIKV isolates. View Full-Text
Keywords: Zika virus; pregnancy; fetal infection; congenital Zika syndrome; Asian lineage Zika virus; pregnancy; fetal infection; congenital Zika syndrome; Asian lineage
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Setoh, Y.X.; Peng, N.Y.; Nakayama, E.; Amarilla, A.A.; Prow, N.A.; Suhrbier, A.; Khromykh, A.A. Fetal Brain Infection Is Not a Unique Characteristic of Brazilian Zika Viruses. Viruses 2018, 10, 541.

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