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Article

Antiviral Activity of Tannic Acid Modified Silver Nanoparticles: Potential to Activate Immune Response in Herpes Genitalis

1
Military Institute of Hygiene and Epidemiology, 01-163 Warsaw, Poland
2
PORT Polish Center for Technology Development, 54-066 Wroclaw, Poland
3
Department of Materials Technology and Chemistry, Faculty of Chemistry, University of Lodz, 90-236 Lodz, Poland
4
Department of Rheumatology & Inflammation research, Gothenburg University, 405 30 Gothenburg, Sweden
*
Author to whom correspondence should be addressed.
Academic Editor: Sherif T. S. Hassan
Viruses 2018, 10(10), 524; https://doi.org/10.3390/v10100524
Received: 31 August 2018 / Revised: 18 September 2018 / Accepted: 19 September 2018 / Published: 26 September 2018
(This article belongs to the Special Issue Recent Advances of Natural Products in HSV Research)
(1) Background: Tannic acid is a plant-derived polyphenol showing antiviral activity mainly because of an interference with the viral adsorption. In this work, we tested whether the modification of silver nanoparticles with tannic acid (TA-AgNPs) can provide a microbicide with additional adjuvant properties to treat genital herpes infection. (2) Methods: The mouse model of the vaginal herpes simplex virus 2 (HSV-2) infection was used to test immune responses after treatment of the primary infection with TA-AgNPs, and later, after a re-challenge with the virus. (3) Results: The mice treated intravaginally with TA-AgNPs showed better clinical scores and lower virus titers in the vaginal tissues soon after treatment. Following a re-challenge, the vaginal tissues treated with TA-AgNPs showed a significant increase in the percentages of IFN-gamma+ CD8+ T-cells, activated B cells, and plasma cells, while the spleens contained significantly higher percentages of IFN-gamma+ NK cells and effector-memory CD8+ T cells in comparison to NaCl-treated group. TA-AgNPs-treated animals also showed significantly better titers of anti-HSV-2 neutralization antibodies in sera; and (4) Conclusions: Our findings suggest that TA-AgNPs sized 33 nm can be an effective anti-viral microbicide to be applied upon the mucosal tissues with additional adjuvant properties enhancing an anti-HSV-2 immune response following secondary challenge. View Full-Text
Keywords: tannic acid; silver nanoparticle; HSV-2 tannic acid; silver nanoparticle; HSV-2
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MDPI and ACS Style

Orłowski, P.; Kowalczyk, A.; Tomaszewska, E.; Ranoszek-Soliwoda, K.; Węgrzyn, A.; Grzesiak, J.; Celichowski, G.; Grobelny, J.; Eriksson, K.; Krzyzowska, M. Antiviral Activity of Tannic Acid Modified Silver Nanoparticles: Potential to Activate Immune Response in Herpes Genitalis. Viruses 2018, 10, 524. https://doi.org/10.3390/v10100524

AMA Style

Orłowski P, Kowalczyk A, Tomaszewska E, Ranoszek-Soliwoda K, Węgrzyn A, Grzesiak J, Celichowski G, Grobelny J, Eriksson K, Krzyzowska M. Antiviral Activity of Tannic Acid Modified Silver Nanoparticles: Potential to Activate Immune Response in Herpes Genitalis. Viruses. 2018; 10(10):524. https://doi.org/10.3390/v10100524

Chicago/Turabian Style

Orłowski, Piotr, Andrzej Kowalczyk, Emilia Tomaszewska, Katarzyna Ranoszek-Soliwoda, Agnieszka Węgrzyn, Jakub Grzesiak, Grzegorz Celichowski, Jarosław Grobelny, Kristina Eriksson, and Malgorzata Krzyzowska. 2018. "Antiviral Activity of Tannic Acid Modified Silver Nanoparticles: Potential to Activate Immune Response in Herpes Genitalis" Viruses 10, no. 10: 524. https://doi.org/10.3390/v10100524

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