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Two Independent Prospectively Planned Blinded Weibull Statistical Analyses of Flexural Strength Data of Zirconia Materials

1
Department of Biostatistics, Epidemiology Biostatistics and Prevention Institute, University of Zurich, Hirschengraben 84, 8001 Zurich, Switzerland
2
Department of Prosthodontics, Dental School, Ludwig-Maximilians-University Munich, Goethestrasse 70, 80336 Munich, Germany
*
Author to whom correspondence should be addressed.
Academic Editors: Nicola Pugno and Dirk Lehmhus
Materials 2016, 9(7), 512; https://doi.org/10.3390/ma9070512
Received: 13 April 2016 / Revised: 17 May 2016 / Accepted: 20 June 2016 / Published: 24 June 2016
Zirconia as a restoration dental material are gaining attention because of their high mechanical properties and good biocompatibility. Therefore, investigation of the flexural strength of zirconia is of great interest. For this purpose, Weibull statistics for description of the material reliability are frequently used. The aim of this work was to present a blinded data set to two independent statisticians for two parallel statistical analyses in order to find an optimal statistical approach for analysis of in-vitro measured flexural strength data of zirconia materials. A prospectively planned independent blinded statistical analysis implementing three quality control actions “blinded data set”, “independent statistical analyses” and “parallel manuscript writing” was designed. Statistical analysis paths taken by both biostatisticians differed. They arrived at complementary results. The major difference was caused by two alternative distributional assumptions (Weibull/Normal) and alternative fitting methods (LS/ML). The parallel statistical analysis and manuscript writing approach on a blinded data set greatly supported our choice of statistical methods for analysis of flexural strength results of zirconia materials. View Full-Text
Keywords: flexural strength data; Weibull analysis; blinded statistical analysis; permutation tests flexural strength data; Weibull analysis; blinded statistical analysis; permutation tests
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Roos, M.; Schatz, C.; Stawarczyk, B. Two Independent Prospectively Planned Blinded Weibull Statistical Analyses of Flexural Strength Data of Zirconia Materials. Materials 2016, 9, 512.

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