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A Novel MgO-CaO-SiO2 System for Fabricating Bone Scaffolds with Improved Overall Performance

State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China
School of Basic Medical Science, Central South University, Changsha 410078, China
College of Chemistry, Xiangtan University, Xiangtan 411105, China
Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha 410011, China
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Juergen Stampfl
Materials 2016, 9(4), 287;
Received: 18 March 2016 / Revised: 5 April 2016 / Accepted: 8 April 2016 / Published: 14 April 2016
(This article belongs to the Section Biomaterials)
PDF [10815 KB, uploaded 14 April 2016]


Although forsterite (Mg2SiO4) possesses good biocompatibility and suitable mechanical properties, the insufficient bioactivity and degradability hinders its further application. In this study, a novel MgO-CaO-SiO2 system was developed by adding wollastonite (CaSiO3) into Mg2SiO4 to fabricate bone scaffolds via selective laser sintering (SLS). The apatite-forming ability and degradability of the scaffolds were enhanced because the degradation of CaSiO3 could form silanol groups, which could offer nucleation sites for apatite. Meanwhile, the mechanical properties of the scaffolds grew with increasing CaSiO3 to 20 wt %. It was explained that the liquid phase of CaSiO3 promoted the densification during sintering due to its low melting point. With the further increase in CaSiO3, the mechanical properties decreased due to the formation of the continuous filling phase. Furthermore, the scaffolds possessed a well-interconnected porous structure and exhibited an ability to support cell adhesion and proliferation. View Full-Text
Keywords: MgO-CaO-SiO2 system; forsterite; wollastonite; scaffold; overall performance MgO-CaO-SiO2 system; forsterite; wollastonite; scaffold; overall performance

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Sun, H.; He, S.; Wu, P.; Gao, C.; Feng, P.; Xiao, T.; Deng, Y.; Shuai, C. A Novel MgO-CaO-SiO2 System for Fabricating Bone Scaffolds with Improved Overall Performance. Materials 2016, 9, 287.

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