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Open AccessArticle

A Novel HA/β-TCP-Collagen Composite Enhanced New Bone Formation for Dental Extraction Socket Preservation in Beagle Dogs

1
School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan
2
Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 106, Taiwan
3
Graduate Institute of Biomedical Materials & Tissue Engineering, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan
4
Dental Department, Taipei Medical University Hospital, Taipei 110, Taiwan
5
Dental Department, Taipei Medical University, Shuang-Ho Hospital, New Taipei 235, Taiwan
*
Author to whom correspondence should be addressed.
The authors are equal contributors to this study.
Academic Editor: Marek M. Kowalczuk
Materials 2016, 9(3), 191; https://doi.org/10.3390/ma9030191
Received: 9 November 2015 / Revised: 7 March 2016 / Accepted: 9 March 2016 / Published: 11 March 2016
(This article belongs to the Special Issue Biodegradable and Bio-Based Polymers)
Past studies in humans have demonstrated horizontal and vertical bone loss after six months following tooth extraction. Many biomaterials have been developed to preserve bone volume after tooth extraction. Type I collagen serves as an excellent delivery system for growth factors and promotes angiogenesis. Calcium phosphate ceramics have also been investigated because their mineral chemistry resembles human bone. The aim of this study was to compare the performance of a novel bioresorbable purified fibrillar collagen and hydroxyapatite/β-tricalcium phosphate (HA/β-TCP) ceramic composite versus collagen alone and a bovine xenograft-collagen composite in beagles. Collagen plugs, bovine graft-collagen composite and HA/β-TCP-collagen composite were implanted into the left and right first, second and third mandibular premolars, and the fourth molar was left empty for natural healing. In total, 20 male beagle dogs were used, and quantitative and histological analyses of the extraction ridge was done. The smallest width reduction was 19.09% ± 8.81% with the HA/β-TCP-collagen composite at Week 8, accompanied by new bone formation at Weeks 4 and 8. The HA/β-TCP-collagen composite performed well, as a new osteoconductive and biomimetic composite biomaterial, for socket bone preservation after tooth extraction. View Full-Text
Keywords: hydroxyapatite; β-tricalcium phosphate; composite; collagen; allograft; socket preservation; animal study hydroxyapatite; β-tricalcium phosphate; composite; collagen; allograft; socket preservation; animal study
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Ho, K.-N.; Salamanca, E.; Chang, K.-C.; Shih, T.-C.; Chang, Y.-C.; Huang, H.-M.; Teng, N.-C.; Lin, C.-T.; Feng, S.-W.; Chang, W.-J. A Novel HA/β-TCP-Collagen Composite Enhanced New Bone Formation for Dental Extraction Socket Preservation in Beagle Dogs. Materials 2016, 9, 191.

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