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Potential of Electrospun Nanofibers for Biomedical and Dental Applications

Department of Restorative Dentistry, College of Dentistry, Taibah University, Madina Munawwarah 41311, Saudi Arabia
Department of Restorative Dental Sciences, Al Farabi Colleges, King Abdullah Road, Riyadh 11313, Saudi Arabia
School of Metallurgy and Materials, University of Birmingham, Birmingham B15 2TT, UK
Department of Biology, Faculty of Science, University of Isfahan, Isfahan 81746-73441, Iran
Department of Biomedical Engineering, College of Engineering, King Faisal University, Al-Hofuf 31982, Saudi Arabia
School of Dentistry, Riyadh College of Dentistry and Pharmacy, P.O. Box 84891, Riyadh 11313, Saudi Arabia
Department of Medical Engineering, University of Bradford, Bradford BD7 1DP, UK
Department of Biomedical Engineering, King Faisal University, Al-Hofuf 31982, Saudi Arabia
Department of Chemistry, Chemical Biology and Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ 07030, USA
Author to whom correspondence should be addressed.
Academic Editor: Nicole Zander
Materials 2016, 9(2), 73;
Received: 29 November 2015 / Revised: 6 January 2016 / Accepted: 18 January 2016 / Published: 26 January 2016
(This article belongs to the Special Issue Electrospun Materials)
PDF [1309 KB, uploaded 26 January 2016]


Electrospinning is a versatile technique that has gained popularity for various biomedical applications in recent years. Electrospinning is being used for fabricating nanofibers for various biomedical and dental applications such as tooth regeneration, wound healing and prevention of dental caries. Electrospun materials have the benefits of unique properties for instance, high surface area to volume ratio, enhanced cellular interactions, protein absorption to facilitate binding sites for cell receptors. Extensive research has been conducted to explore the potential of electrospun nanofibers for repair and regeneration of various dental and oral tissues including dental pulp, dentin, periodontal tissues, oral mucosa and skeletal tissues. However, there are a few limitations of electrospinning hindering the progress of these materials to practical or clinical applications. In terms of biomaterials aspects, the better understanding of controlled fabrication, properties and functioning of electrospun materials is required to overcome the limitations. More in vivo studies are definitely required to evaluate the biocompatibility of electrospun scaffolds. Furthermore, mechanical properties of such scaffolds should be enhanced so that they resist mechanical stresses during tissue regeneration applications. The objective of this article is to review the current progress of electrospun nanofibers for biomedical and dental applications. In addition, various aspects of electrospun materials in relation to potential dental applications have been discussed. View Full-Text
Keywords: dentistry; dental materials; nanomaterials; nanotechnology; tissue engineering; regeneration dentistry; dental materials; nanomaterials; nanotechnology; tissue engineering; regeneration

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Zafar, M.; Najeeb, S.; Khurshid, Z.; Vazirzadeh, M.; Zohaib, S.; Najeeb, B.; Sefat, F. Potential of Electrospun Nanofibers for Biomedical and Dental Applications. Materials 2016, 9, 73.

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