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Materials 2016, 9(12), 1028;

Synthesis and Structural Characterization of Silver Nanoparticles Stabilized with 3-Mercapto-1-Propansulfonate and 1-Thioglucose Mixed Thiols for Antibacterial Applications

Department of Sciences, Roma Tre University, Via della Vasca Navale 79, 00146 Rome, Italy
Department of Chemistry, Sapienza University, P.le A. Moro 5, 00085 Rome, Italy
Alba Synchrotron Facility, Carrer de la Llum, 2-26, Cerdanyola del Vallès, 08290 Barcelona, Spain
Faculty of Physics, University of Bialystok, 1L K. Ciolkowskiego street, 15-245 Bialystok, Poland
Author to whom correspondence should be addressed.
Academic Editor: Erik Reimhult
Received: 22 November 2016 / Revised: 14 December 2016 / Accepted: 15 December 2016 / Published: 20 December 2016
(This article belongs to the Special Issue Noble Metal Nanoparticles)
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The synthesis, characterization and assessment of the antibacterial properties of hydrophilic silver nanoparticles (AgNPs) were investigated with the aim to probe their suitability for innovative applications in the field of nanobiotechnology. First, silver nanoparticles were synthetized and functionalized with two capping agents, namely 3-mercapto-1-propansulfonate (3MPS) and 1-β-thio-d-glucose (TG). The investigation of the structural and electronic properties of the nano-systems was carried out by means of X-ray Photoelectron Spectroscopy (XPS) and X-ray Absorption Spectroscopy (XAS). XPS data provided information about the system stability and the interactions between the metallic surface and the organic ligands. In addition, XPS data allowed us to achieve a deep understanding of the influence of the thiols stoichiometric ratio on the electronic properties and stability of AgNPs. In order to shed light on the structural and electronic local properties at Ag atoms sites, XAS at Ag K-Edge was successfully applied; furthermore, the combination of Dynamic Light Scattering (DLS) and XAS results allowed determining AgNPs sizes, ranging between 3 and 13 nm. Finally, preliminary studies on the antibacterial properties of AgNPs showed promising results on four of six multidrug-resistant bacteria belonging to the ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter sp.). View Full-Text
Keywords: silver nanoparticles; antibacterial activity; hydrophilic ligands silver nanoparticles; antibacterial activity; hydrophilic ligands

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Porcaro, F.; Carlini, L.; Ugolini, A.; Visaggio, D.; Visca, P.; Fratoddi, I.; Venditti, I.; Meneghini, C.; Simonelli, L.; Marini, C.; Olszewski, W.; Ramanan, N.; Luisetto, I.; Battocchio, C. Synthesis and Structural Characterization of Silver Nanoparticles Stabilized with 3-Mercapto-1-Propansulfonate and 1-Thioglucose Mixed Thiols for Antibacterial Applications. Materials 2016, 9, 1028.

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