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Materials 2016, 9(12), 1002;

Cellulose Nanocrystal Membranes as Excipients for Drug Delivery Systems

Postgraduated Program in Science and Material Engineering, Technology Development Center, Federal University of Pelotas, Gomes Carneiro 1, Pelotas-RS 96010-610, Brazil
Chemical & Environmental Engineering Department, University of the Basque Country UPV/EHU, Plaza Europa 1, Donostia-San Sebastian 20018, Spain
Postgraduate Program in Dentistry, Federal University of Pelotas, Gonçalves Chaves 457, Pelotas-RS 96015-560, Brazil
Author to whom correspondence should be addressed.
Academic Editor: Tommaso Carofiglio
Received: 30 October 2016 / Revised: 18 November 2016 / Accepted: 2 December 2016 / Published: 12 December 2016
(This article belongs to the Special Issue Nanocellulose-Based Functional Materials)
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In this work, cellulose nanocrystals (CNCs) were obtained from flax fibers by an acid hydrolysis assisted by sonochemistry in order to reduce reaction times. The cavitation inducted during hydrolysis resulted in CNC with uniform shapes, and thus further pretreatments into the cellulose are not required. The obtained CNC exhibited a homogeneous morphology and high crystallinity, as well as typical values for surface charge. Additionally, CNC membranes were developed from CNC solution to evaluation as a drug delivery system by the incorporation of a model drug. The drug delivery studies were carried out using chlorhexidine (CHX) as a drug and the antimicrobial efficiency of the CNC membrane loaded with CHX was examined against Gram-positive bacteria Staphylococcus aureus (S. Aureus). The release of CHX from the CNC membranes is determined by UV-Vis. The obtaining methodology of the membranes proved to be simple, and these early studies showed a potential use in antibiotic drug delivery systems due to the release kinetics and the satisfactory antimicrobial activity. View Full-Text
Keywords: cellulose nanocrystals; chlorhexidine; Staphylococcus aureus cellulose nanocrystals; chlorhexidine; Staphylococcus aureus

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Barbosa, A.M.; Robles, E.; Ribeiro, J.S.; Lund, R.G.; Carreño, N.L.V.; Labidi, J. Cellulose Nanocrystal Membranes as Excipients for Drug Delivery Systems. Materials 2016, 9, 1002.

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