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Materials 2016, 9(11), 864;

An Intriguing Method for Fabricating Arbitrarily Shaped “Matreshka” Hydrogels Using a Self-Healing Template

Graduate School of Pure and Applied Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan
International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan
Japan Society for the Promotion of Science (JSPS), 5-3-1, Kojimachi, Chiyoda-ku, Tokyo 102-0083, Japan
Graduate School of Industrial Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585, Japan
Author to whom correspondence should be addressed.
Academic Editor: Peter Dubruel
Received: 30 September 2016 / Revised: 14 October 2016 / Accepted: 18 October 2016 / Published: 25 October 2016
(This article belongs to the Special Issue Smart Hydrogels for (Bio)printing Applications)
Full-Text   |   PDF [3665 KB, uploaded 25 October 2016]   |  


This work describes an intriguing strategy for the creation of arbitrarily shaped hydrogels utilizing a self-healing template (SHT). A SHT was loaded with a photo-crosslinkable monomer, PEG diacrylate (PEGDA), and then ultraviolet light (UV) crosslinked after first shaping. The SHT template was removed by simple washing with water, leaving behind the hydrogel in the desired physical shape. A hierarchical 3D structure such as “Matreshka” boxes were successfully prepared by simply repeating the “self-healing” and “photo-irradiation” processes. We have also explored the potential of the SHT system for the manipulation of cells. View Full-Text
Keywords: self-healing material; hydrogel fabrication; biocompatible polymer self-healing material; hydrogel fabrication; biocompatible polymer

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Sato, T.; Uto, K.; Aoyagi, T.; Ebara, M. An Intriguing Method for Fabricating Arbitrarily Shaped “Matreshka” Hydrogels Using a Self-Healing Template. Materials 2016, 9, 864.

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