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Advanced Engineering Strategies for Periodontal Complex Regeneration

Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 330-714, Korea
Department of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul 110-749, Korea
Author to whom correspondence should be addressed.
Academic Editors: C. Edi Tanase, Michael Nerlich and Arne Berner
Materials 2016, 9(1), 57;
Received: 16 December 2015 / Revised: 7 January 2016 / Accepted: 8 January 2016 / Published: 18 January 2016
(This article belongs to the Special Issue Regenerative Materials)
The regeneration and integration of multiple tissue types is critical for efforts to restore the function of musculoskeletal complex. In particular, the neogenesis of periodontal constructs for systematic tooth-supporting functions is a current challenge due to micron-scaled tissue compartmentalization, oblique/perpendicular orientations of fibrous connective tissues to the tooth root surface and the orchestration of multiple regenerated tissues. Although there have been various biological and biochemical achievements, periodontal tissue regeneration remains limited and unpredictable. The purpose of this paper is to discuss current advanced engineering approaches for periodontal complex formations; computer-designed, customized scaffolding architectures; cell sheet technology-based multi-phasic approaches; and patient-specific constructs using bioresorbable polymeric material and 3-D printing technology for clinical application. The review covers various advanced technologies for periodontal complex regeneration and state-of-the-art therapeutic avenues in periodontal tissue engineering. View Full-Text
Keywords: periodontal tissue complex; multiple tissue formation; cell sheet engineering; 3-D printing technology periodontal tissue complex; multiple tissue formation; cell sheet engineering; 3-D printing technology
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Park, C.H.; Kim, K.-H.; Lee, Y.-M.; Seol, Y.-J. Advanced Engineering Strategies for Periodontal Complex Regeneration. Materials 2016, 9, 57.

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