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Modification of pH Conferring Virucidal Activity on Dental Alginates

Department of Oral Growth and Development, Queen Mary, University of London, London E1 4NS, UK
Queen Mary BioEnterprises, Innovation Centre, London E1 2AX, UK
Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, London E1 2AT, UK
Author to whom correspondence should be addressed.
Academic Editor: Ihtesham ur Rehman
Materials 2015, 8(4), 1966-1975;
Received: 13 February 2015 / Revised: 26 March 2015 / Accepted: 13 April 2015 / Published: 21 April 2015
(This article belongs to the Special Issue Dental Materials)
PDF [602 KB, uploaded 21 April 2015]


To formulate an alginate dental impression material with virucidal properties, experimental alginate dental impression materials were developed and the formulations adjusted in order to study the effect on pH profiles during setting. Commercially available materials served as a comparison. Eight experimental materials were tested for antiviral activity against Herpes Simplex Virus type 1 (HSV-1). Changing the amount of magnesium oxide (MgO) used in the experimental formulations had a marked effect on pH. Increasing MgO concentration corresponded with increased pH values. All experimental materials brought about viral log reductions ranging between 0.5 and 4.0 over a period of 4 h. The material with the lowest pH was the most effective. The current work highlights the very important role of MgO in controlling pH profiles. This knowledge has been applied to the formulation of experimental alginates; where materials with pH values of approximately 4.2–4.4 are able to achieve a significant log reduction when assayed against HSV-1. View Full-Text
Keywords: alginate; pH; antiviral; Herpes Simplex Virus type 1; magnesium oxide alginate; pH; antiviral; Herpes Simplex Virus type 1; magnesium oxide

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MDPI and ACS Style

Nallamuthu, N.; Braden, M.; Oxford, J.; Williams, D.; Patel, M. Modification of pH Conferring Virucidal Activity on Dental Alginates. Materials 2015, 8, 1966-1975.

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