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Substrate Effects on the Formation Process, Structure and Physicochemical Properties of Supported Lipid Bilayers

Electronics-Inspired Interdisciplinary Research Institute (EIIRIS), Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi 441-8580, Japan
Materials 2012, 5(12), 2658-2680; https://doi.org/10.3390/ma5122658
Received: 29 September 2012 / Revised: 29 November 2012 / Accepted: 29 November 2012 / Published: 7 December 2012
(This article belongs to the Special Issue Supported Lipid Membranes)
Supported lipid bilayers are artificial lipid bilayer membranes existing at the interface between solid substrates and aqueous solution. Surface structures and properties of the solid substrates affect the formation process, fluidity, two-dimensional structure and chemical activity of supported lipid bilayers, through the 1–2 nm thick water layer between the substrate and bilayer membrane. Even on SiO2/Si and mica surfaces, which are flat and biologically inert, and most widely used as the substrates for the supported lipid bilayers, cause differences in the structure and properties of the supported membranes. In this review, I summarize several examples of the effects of substrate structures and properties on an atomic and nanometer scales on the solid-supported lipid bilayers, including our recent reports. View Full-Text
Keywords: lipid bilayer membranes; silicon oxide; mica; titanium dioxide; atomic force microscope; fluorescence microscope; single molecule tracking; surface hydrophilicity; anomalous diffusion; phase separation lipid bilayer membranes; silicon oxide; mica; titanium dioxide; atomic force microscope; fluorescence microscope; single molecule tracking; surface hydrophilicity; anomalous diffusion; phase separation
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Tero, R. Substrate Effects on the Formation Process, Structure and Physicochemical Properties of Supported Lipid Bilayers. Materials 2012, 5, 2658-2680.

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