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Open AccessArticle

Multi-Echo-Based Echo-Planar Spectroscopic Imaging Using a 3T MRI Scanner

Department of Radiological Sciences, University of California, Los Angeles, CA 90095, USA
Medical Imaging Informatics (MII) Lab, University of California, Los Angeles, CA 90095, USA
Author to whom correspondence should be addressed.
Materials 2011, 4(10), 1818-1834;
Received: 2 September 2011 / Revised: 6 October 2011 / Accepted: 7 October 2011 / Published: 17 October 2011
(This article belongs to the Special Issue High Field Magnetic Resonance Methods and Materials)
The use of spin-echoes has been employed in an Echo-Planar Spectroscopic Imaging (EPSI) sequence to collect multiple phase encoded lines within a single TR in a Multi-Echo-based Echo-Planar Spectroscopic Imaging technique (MEEPSI). Despite the T2 dependence on the amplitude of the spin-echoes, the Full Width at Half Maximum (FWHM) of the derived multi-echo Point Spread Function (PSF) is shown to decrease, indicating an improved overall spatial resolution without requiring any additional scan time. The improved spatial resolution is demonstrated in the one-dimensional (1D) spatial profiles of the N-Acetyl Aspartate (NAA) singlet along the phase encode dimension in a gray matter phantom. Although the improved spatial resolution comes at the expense of spectral resolution, it is shown in vivo that peak broadening due to T2* decay is more significant than the loss of resolution from using spin-echoes and therefore does not affect the ability to quantify metabolites using the LCModel fitting algorithm. View Full-Text
Keywords: multi-echo; echo-planar spectroscopic imaging multi-echo; echo-planar spectroscopic imaging
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Furuyama, J.K.; Burns, B.L.; Wilson, N.E.; Thomas, M.A. Multi-Echo-Based Echo-Planar Spectroscopic Imaging Using a 3T MRI Scanner. Materials 2011, 4, 1818-1834.

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