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Materials 2010, 3(9), 4607-4625;

Creating Surface Properties Using a Palette of Hydrophobins

Microbiology, Institute of Biomembranes, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
BiOMaDe Technology Foundation, Nijenborgh 4, 9747 AG Groningen, The Netherlands
Department of Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, PO Box 14, 9750 AA Haren, The Netherlands
Author to whom correspondence should be addressed.
Received: 9 August 2010 / Revised: 20 August 2010 / Accepted: 3 September 2010 / Published: 6 September 2010
(This article belongs to the Special Issue Advances in Surface Coatings)
Full-Text   |   PDF [912 KB, uploaded 6 September 2010]   |  


Small secreted proteins called hydrophobins play diverse roles in the life cycle of filamentous fungi. For example, the hydrophobin SC3 of Schizophyllum commune is involved in aerial hyphae formation, cell-wall assembly and attachment to hydrophobic surfaces. Hydrophobins are capable of self-assembly at a hydrophilic-hydrophobic interface, resulting in the formation of an amphipathic film. This amphipathic film can make hydrophobic surfaces of a liquid or a solid material wettable, while a hydrophilic surface can be turned into a hydrophobic one. These properties, among others, make hydrophobins of interest for medical and technical applications. For instance, hydrophobins can be used to purify proteins from complex mixtures; to reduce the friction of materials; to increase the biocompatibility of medical implants; to increase the solubility of water insoluble drugs; and to immobilize enzymes, for example, biosensor surfaces. View Full-Text
Keywords: hydrophobin; self-assembly; wettability; coating of surfaces; immobilization hydrophobin; self-assembly; wettability; coating of surfaces; immobilization

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Zampieri, F.; Wösten, H.A.B.; Scholtmeijer, K. Creating Surface Properties Using a Palette of Hydrophobins. Materials 2010, 3, 4607-4625.

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