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Open AccessArticle

Synthesis and Characterization of Multifunctional Chitosan- MnFe2O4 Nanoparticles for Magnetic Hyperthermia and Drug Delivery

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Department of Chemical and Biological Engineering, Box 870203, The University of Alabama, Tuscaloosa, AL 35487-0203, USA
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Department of Chemistry and Center for Materials for Information Technology, Box 870336, The University of Alabama, Tuscaloosa, AL 35487, USA
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Author to whom correspondence should be addressed.
Materials 2010, 3(7), 4051-4065; https://doi.org/10.3390/ma3074051
Received: 20 May 2010 / Accepted: 1 July 2010 / Published: 13 July 2010
(This article belongs to the Special Issue Magnetic Nanoparticles)
Multifunctional nanoparticles composed of MnFe2O4 were encapsulated in chitosan for investigation of system to combine magnetically-triggered drug delivery and localized hyperthermia for cancer treatment with the previously published capacity of MnFe2O4 to be used as an efficient MRI contrast agent for cancer diagnosis. This paper focuses on the synthesis and characterization of magnetic MnFe2O4 nanoparticles, their dispersion in water and their incorporation in chitosan, which serves as a drug carrier. The surface of the MnFe2O4 nanoparticles was modified with meso-2,3-di-mercaptosuccinic acid (DMSA) to develop stable aqueous dispersions. The nanoparticles were coated with chitosan, and the magnetic properties, heat generation and hydrodynamic size of chitosan-coated MnFe2O4 were evaluated for various linker concentrations and in a range of pH conditions. View Full-Text
Keywords: multifunctional magnetic nanoparticles; chitosan; MnFe2O4 nanoparticles; magnetic hyperthermia; drug delivery multifunctional magnetic nanoparticles; chitosan; MnFe2O4 nanoparticles; magnetic hyperthermia; drug delivery
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Kim, D.-H.; Nikles, D.E.; Brazel, C.S. Synthesis and Characterization of Multifunctional Chitosan- MnFe2O4 Nanoparticles for Magnetic Hyperthermia and Drug Delivery. Materials 2010, 3, 4051-4065.

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