Next Article in Journal
The Electrochemical Behavior of Ti in Human Synovial Fluids
Previous Article in Journal
Geopolymers and Functionalization Strategies for the Development of Sustainable Materials in Construction Industry and Cultural Heritage Applications: A Review
Previous Article in Special Issue
Stimulation of Metabolic Activity and Cell Differentiation in Osteoblastic and Human Mesenchymal Stem Cells by a Nanohydroxyapatite Paste Bone Graft Substitute
Review

Strontium Functionalization of Biomaterials for Bone Tissue Engineering Purposes: A Biological Point of View

1
Department of Biomedical and Neuromotor Sciences, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
2
Biomedical Science and Technologies Laboratory, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano 1/10, 40136 Bologna, Italy
3
Laboratory for Nanobiotechnology, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano 1/10, 40136 Bologna, Italy
4
Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Kátia F Fernandes and Karla A. Batista
Materials 2022, 15(5), 1724; https://doi.org/10.3390/ma15051724
Received: 29 December 2021 / Revised: 18 February 2022 / Accepted: 20 February 2022 / Published: 25 February 2022
(This article belongs to the Special Issue Bioactive and Functional Materials)
Strontium (Sr) is a trace element taken with nutrition and found in bone in close connection to native hydroxyapatite. Sr is involved in a dual mechanism of coupling the stimulation of bone formation with the inhibition of bone resorption, as reported in the literature. Interest in studying Sr has increased in the last decades due to the development of strontium ranelate (SrRan), an orally active agent acting as an anti-osteoporosis drug. However, the use of SrRan was subjected to some limitations starting from 2014 due to its negative side effects on the cardiac safety of patients. In this scenario, an interesting perspective for the administration of Sr is the introduction of Sr ions in biomaterials for bone tissue engineering (BTE) applications. This strategy has attracted attention thanks to its positive effects on bone formation, alongside the reduction of osteoclast activity, proven by in vitro and in vivo studies. The purpose of this review is to go through the classes of biomaterials most commonly used in BTE and functionalized with Sr, i.e., calcium phosphate ceramics, bioactive glasses, metal-based materials, and polymers. The works discussed in this review were selected as representative for each type of the above-mentioned categories, and the biological evaluation in vitro and/or in vivo was the main criterion for selection. The encouraging results collected from the in vitro and in vivo biological evaluations are outlined to highlight the potential applications of materials’ functionalization with Sr as an osteopromoting dopant in BTE. View Full-Text
Keywords: strontium; strontium ranelate; osteoblast; osteoclast; bone tissue engineering; scaffolds; calcium phosphate ceramics; bioactive glasses; metal-based materials; polymers strontium; strontium ranelate; osteoblast; osteoclast; bone tissue engineering; scaffolds; calcium phosphate ceramics; bioactive glasses; metal-based materials; polymers
Show Figures

Graphical abstract

MDPI and ACS Style

Borciani, G.; Ciapetti, G.; Vitale-Brovarone, C.; Baldini, N. Strontium Functionalization of Biomaterials for Bone Tissue Engineering Purposes: A Biological Point of View. Materials 2022, 15, 1724. https://doi.org/10.3390/ma15051724

AMA Style

Borciani G, Ciapetti G, Vitale-Brovarone C, Baldini N. Strontium Functionalization of Biomaterials for Bone Tissue Engineering Purposes: A Biological Point of View. Materials. 2022; 15(5):1724. https://doi.org/10.3390/ma15051724

Chicago/Turabian Style

Borciani, Giorgia, Gabriela Ciapetti, Chiara Vitale-Brovarone, and Nicola Baldini. 2022. "Strontium Functionalization of Biomaterials for Bone Tissue Engineering Purposes: A Biological Point of View" Materials 15, no. 5: 1724. https://doi.org/10.3390/ma15051724

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop