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Improving Polysaccharide-Based Chitin/Chitosan-Aerogel Materials by Learning from Genetics and Molecular Biology

1
Institute of Biology, Leipzig University, Philipp-Rosenthal-Str. 55, 04103 Leipzig, Germany
2
German Aerospace Center, Institute of Materials Research, Linder Höhe, 51147 Cologne, Germany
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Author to whom correspondence should be addressed.
Academic Editors: Morena Nocchetti, Paula Coutinho and Maximiano Ribeiro
Materials 2022, 15(3), 1041; https://doi.org/10.3390/ma15031041
Received: 22 November 2021 / Revised: 14 January 2022 / Accepted: 26 January 2022 / Published: 28 January 2022
(This article belongs to the Special Issue Materials for Skin Tissue Engineering)
Improved wound healing of burnt skin and skin lesions, as well as medical implants and replacement products, requires the support of synthetical matrices. Yet, producing synthetic biocompatible matrices that exhibit specialized flexibility, stability, and biodegradability is challenging. Synthetic chitin/chitosan matrices may provide the desired advantages for producing specialized grafts but must be modified to improve their properties. Synthetic chitin/chitosan hydrogel and aerogel techniques provide the advantages for improvement with a bioinspired view adapted from the natural molecular toolbox. To this end, animal genetics provide deep knowledge into which molecular key factors decisively influence the properties of natural chitin matrices. The genetically identified proteins and enzymes control chitin matrix assembly, architecture, and degradation. Combining synthetic chitin matrices with critical biological factors may point to the future direction with engineering materials of specific properties for biomedical applications such as burned skin or skin blistering and extensive lesions due to genetic diseases. View Full-Text
Keywords: wound healing; materials; skin substitutes; aerogel; chitin; chitosan; insect; drosophila; proteins; obst-A wound healing; materials; skin substitutes; aerogel; chitin; chitosan; insect; drosophila; proteins; obst-A
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MDPI and ACS Style

Behr, M.; Ganesan, K. Improving Polysaccharide-Based Chitin/Chitosan-Aerogel Materials by Learning from Genetics and Molecular Biology. Materials 2022, 15, 1041. https://doi.org/10.3390/ma15031041

AMA Style

Behr M, Ganesan K. Improving Polysaccharide-Based Chitin/Chitosan-Aerogel Materials by Learning from Genetics and Molecular Biology. Materials. 2022; 15(3):1041. https://doi.org/10.3390/ma15031041

Chicago/Turabian Style

Behr, Matthias, and Kathirvel Ganesan. 2022. "Improving Polysaccharide-Based Chitin/Chitosan-Aerogel Materials by Learning from Genetics and Molecular Biology" Materials 15, no. 3: 1041. https://doi.org/10.3390/ma15031041

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