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Article

3D Plotting of Silica/Collagen Xerogel Granules in an Alginate Matrix for Tissue-Engineered Bone Implants

1
Max Bergmann Center of Biomaterials and Institute of Materials Science, Technische Universität Dresden, 01069 Dresden, Germany
2
Institute of Textile Machinery and High Performance Materials Technology, TU Dresden, 01069 Dresden, Germany
*
Author to whom correspondence should be addressed.
Academic Editors: Filip Górski and Artemis Stamboulis
Materials 2021, 14(4), 830; https://doi.org/10.3390/ma14040830
Received: 22 December 2020 / Revised: 20 January 2021 / Accepted: 4 February 2021 / Published: 9 February 2021
(This article belongs to the Special Issue 3D Printing in Medicine and Biomedical Engineering)
Today, materials designed for bone regeneration are requested to be degradable and resorbable, bioactive, porous, and osteoconductive, as well as to be an active player in the bone-remodeling process. Multiphasic silica/collagen Xerogels were shown, earlier, to meet these requirements. The aim of the present study was to use these excellent material properties of silica/collagen Xerogels and to process them by additive manufacturing, in this case 3D plotting, to generate implants matching patient specific shapes of fractures or lesions. The concept is to have Xerogel granules as active major components embedded, to a large proportion, in a matrix that binds the granules in the scaffold. By using viscoelastic alginate as matrix, pastes of Xerogel granules were processed via 3D plotting. Moreover, alginate concentration was shown to be the key to a high content of irregularly shaped Xerogel granules embedded in a minimum of matrix phase. Both the alginate matrix and Xerogel granules were also shown to influence viscoelastic behavior of the paste, as well as the dimensionally stability of the scaffolds. In conclusion, 3D plotting of Xerogel granules was successfully established by using viscoelastic properties of alginate as matrix phase. View Full-Text
Keywords: silica/collagen composite; additive manufacturing; biomaterial ink; rheology; tissue-engineered bone implant silica/collagen composite; additive manufacturing; biomaterial ink; rheology; tissue-engineered bone implant
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MDPI and ACS Style

Rößler, S.; Brückner, A.; Kruppke, I.; Wiesmann, H.-P.; Hanke, T.; Kruppke, B. 3D Plotting of Silica/Collagen Xerogel Granules in an Alginate Matrix for Tissue-Engineered Bone Implants. Materials 2021, 14, 830. https://doi.org/10.3390/ma14040830

AMA Style

Rößler S, Brückner A, Kruppke I, Wiesmann H-P, Hanke T, Kruppke B. 3D Plotting of Silica/Collagen Xerogel Granules in an Alginate Matrix for Tissue-Engineered Bone Implants. Materials. 2021; 14(4):830. https://doi.org/10.3390/ma14040830

Chicago/Turabian Style

Rößler, Sina, Andreas Brückner, Iris Kruppke, Hans-Peter Wiesmann, Thomas Hanke, and Benjamin Kruppke. 2021. "3D Plotting of Silica/Collagen Xerogel Granules in an Alginate Matrix for Tissue-Engineered Bone Implants" Materials 14, no. 4: 830. https://doi.org/10.3390/ma14040830

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