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Article

Fabrication of Piezoelectric Electrospun Termite Nest-like 3D Scaffolds for Tissue Engineering

1
Institute of Science, School of Physics, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand
2
Thailand Center of Excellence in Physics (ThEP), Ministry of Higher Education, Science, Research and Innovation, Bangkok 10400, Thailand
3
Institute of Science, School of Preclinical Sciences, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand
4
Center of Excellence on Advanced Functional Materials (CoE-AFM), Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand
5
Institute for Materials and Processes, School of Engineering, The University of Edinburgh, Robert Stevenson Road, Edinburgh EH9 3FB, UK
6
Research Network NANOTEC—SUT on Advanced Nanomaterials and Characterization, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand
*
Authors to whom correspondence should be addressed.
Academic Editors: Tsz Ho Kwo, Xiangjia Li and Yang Yang
Materials 2021, 14(24), 7684; https://doi.org/10.3390/ma14247684
Received: 3 November 2021 / Revised: 29 November 2021 / Accepted: 8 December 2021 / Published: 13 December 2021
(This article belongs to the Special Issue Design and Manufacturing of Bioinspired Material and Structures)
A high piezoelectric coefficient polymer and biomaterial for bone tissue engineering— poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP)—has been successfully fabricated into 3D scaffolds using the wet electrospinning method. Three-dimensional (3D) scaffolds have significant advantages for tissue engineering applications. Electrospinning is an advanced method and can fabricate 3D scaffolds. However, it has some limitations and is difficult to fabricate nanofibers into 3D shapes because of the low controllability of porosity and internal pore shape. The PVDF-HFP powders were dissolved in a mixture of acetone and dimethylformamide with a ratio of 1:1 at various concentrations of 10, 13, 15, 17, and 20 wt%. However, only the solutions at 15 and 17 wt% with optimized electrospinning parameters can be fabricated into biomimetic 3D shapes. The produced PVDF-HFP 3D scaffolds are in the cm size range and mimic the structure of the natural nests of termites of the genus Apicotermes. In addition, the 3D nanofiber-based structure can also generate more electrical signals than the conventional 2D ones, as the third dimension provides more compression. The cell interaction with the 3D nanofibers scaffold was investigated. The in vitro results demonstrated that the NIH 3T3 cells could attach and migrate in the 3D structures. While conventional electrospinning yields 2D (flat) structures, our bio-inspired electrospun termite nest-like 3D scaffolds are better suited for tissue engineering applications since they can potentially mimic native tissues as they have biomimetic structure, piezoelectric, and biological properties.
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Keywords: 3D scaffold; electrospinning; poly(vinylidene fluoride); tissue engineering; piezoelectric 3D scaffold; electrospinning; poly(vinylidene fluoride); tissue engineering; piezoelectric
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MDPI and ACS Style

Muenwacha, T.; Weeranantanapan, O.; Chudapongse, N.; Diaz Sanchez, F.J.; Maensiri, S.; Radacsi, N.; Nuansing, W. Fabrication of Piezoelectric Electrospun Termite Nest-like 3D Scaffolds for Tissue Engineering. Materials 2021, 14, 7684. https://doi.org/10.3390/ma14247684

AMA Style

Muenwacha T, Weeranantanapan O, Chudapongse N, Diaz Sanchez FJ, Maensiri S, Radacsi N, Nuansing W. Fabrication of Piezoelectric Electrospun Termite Nest-like 3D Scaffolds for Tissue Engineering. Materials. 2021; 14(24):7684. https://doi.org/10.3390/ma14247684

Chicago/Turabian Style

Muenwacha, Thanapon, Oratai Weeranantanapan, Nuannoi Chudapongse, Francisco J. Diaz Sanchez, Santi Maensiri, Norbert Radacsi, and Wiwat Nuansing. 2021. "Fabrication of Piezoelectric Electrospun Termite Nest-like 3D Scaffolds for Tissue Engineering" Materials 14, no. 24: 7684. https://doi.org/10.3390/ma14247684

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