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Article

Production, Characterization and Application of Oxide Nanotubes on Ti–6Al–7Nb Alloy as a Potential Drug Carrier

1
Institute of Materials Engineering, Faculty of Science and Technology, University of Silesia in Katowice, 75 Pułku Piechoty 1A, 41-500 Chorzów, Poland
2
Łukasiewicz Research Network, Institute of Ceramics and Building Materials, Refractory Materials Division, Toszecka 99, 44-100 Gliwice, Poland
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The August Chełkowski Institute of Physics, University of Silesia in Katowice, 75 Pułku Piechoty 1A, 41-500 Chorzów, Poland
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Faculty of Mechanical Engineering, Silesian University of Technology, Konarskiego 18a, 44-100 Gliwice, Poland
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Foundation of Cardiac Surgery Development, Artificial Heart Laboratory, Wolności 345a, 41-800 Zabrze, Poland
6
Old Machar Medical Practice, 526-528 King Street, Aberdeen AB24 5RS, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Silvie Rimpelová
Materials 2021, 14(20), 6142; https://doi.org/10.3390/ma14206142
Received: 15 September 2021 / Revised: 7 October 2021 / Accepted: 12 October 2021 / Published: 16 October 2021
(This article belongs to the Special Issue Advanced Functional Materials for Biomedicinal Applications)
This work concerns the development of a method of functionalization of the surface of the biomedical Ti–6Al–7Nb alloy by producing oxide nanotubes (ONTs) with drug-eluting properties. Shaping of the morphology, microstructure, and thickness of the oxide layer was carried out by anodization in an aqueous solution of 1 M ethylene glycol with the addition of 0.2 M NH4F in the voltage range 5–100 V for 15–60 min at room temperature. The characterization of the physicochemical properties of the obtained ONTs was performed using SEM, XPS, and EDAX methods. ONTs have been shown to be composed mainly of TiO2, Al2O3, and Nb2O5. Single-walled ONTs with the largest specific surface area of 600 cm2 cm−2 can be obtained by anodization at 50 V for 60 min. The mechanism of ONT formation on the Ti–6Al–7Nb alloy was studied in detail. Gentamicin sulfate loaded into ONTs was studied using FTIR, TG, DTA, and DTG methods. Drug release kinetics was determined by UV–Vis spectrophotometry. The obtained ONTs can be proposed for use in modern implantology as carriers for drugs delivered locally in inflammatory conditions. View Full-Text
Keywords: anodic oxidation; biomaterials; drug delivery system; gentamicin; oxide nanotubes; titanium alloys anodic oxidation; biomaterials; drug delivery system; gentamicin; oxide nanotubes; titanium alloys
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MDPI and ACS Style

Łosiewicz, B.; Stróż, A.; Osak, P.; Maszybrocka, J.; Gerle, A.; Dudek, K.; Balin, K.; Łukowiec, D.; Gawlikowski, M.; Bogunia, S. Production, Characterization and Application of Oxide Nanotubes on Ti–6Al–7Nb Alloy as a Potential Drug Carrier. Materials 2021, 14, 6142. https://doi.org/10.3390/ma14206142

AMA Style

Łosiewicz B, Stróż A, Osak P, Maszybrocka J, Gerle A, Dudek K, Balin K, Łukowiec D, Gawlikowski M, Bogunia S. Production, Characterization and Application of Oxide Nanotubes on Ti–6Al–7Nb Alloy as a Potential Drug Carrier. Materials. 2021; 14(20):6142. https://doi.org/10.3390/ma14206142

Chicago/Turabian Style

Łosiewicz, Bożena, Agnieszka Stróż, Patrycja Osak, Joanna Maszybrocka, Anna Gerle, Karolina Dudek, Katarzyna Balin, Dariusz Łukowiec, Maciej Gawlikowski, and Sylwia Bogunia. 2021. "Production, Characterization and Application of Oxide Nanotubes on Ti–6Al–7Nb Alloy as a Potential Drug Carrier" Materials 14, no. 20: 6142. https://doi.org/10.3390/ma14206142

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