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Article

3D Printing of Piezoelectric Barium Titanate-Hydroxyapatite Scaffolds with Interconnected Porosity for Bone Tissue Engineering

1
Chair of Microfluidics, University of Rostock, 18059 Rostock, Germany
2
Institute of Biomaterials, Friedrich Alexander University Erlangen-Nuremberg, 91058 Erlangen, Germany
3
Leibniz Institute for Catalysis at the University of Rostock, 18059 Rostock, Germany
4
Electron microscopy centrum, University Hospital Rostock, 18057 Rostock, Germany
5
Department Life, Light & Matter, University of Rostock, 18059 Rostock, Germany
*
Author to whom correspondence should be addressed.
Authors contributed equally.
Materials 2020, 13(7), 1773; https://doi.org/10.3390/ma13071773
Received: 10 March 2020 / Revised: 30 March 2020 / Accepted: 6 April 2020 / Published: 9 April 2020
(This article belongs to the Special Issue Bioceramic Composites for Biomedical Applications)
The prevalence of large bone defects is still a major problem in surgical clinics. It is, thus, not a surprise that bone-related research, especially in the field of bone tissue engineering, is a major issue in medical research. Researchers worldwide are searching for the missing link in engineering bone graft materials that mimic bones, and foster osteogenesis and bone remodeling. One approach is the combination of additive manufacturing technology with smart and additionally electrically active biomaterials. In this study, we performed a three-dimensional (3D) printing process to fabricate piezoelectric, porous barium titanate (BaTiO3) and hydroxyapatite (HA) composite scaffolds. The printed scaffolds indicate good cytocompatibility and cell attachment as well as bone mimicking piezoelectric properties with a piezoelectric constant of 3 pC/N. This work represents a promising first approach to creating an implant material with improved bone regenerating potential, in combination with an interconnected porous network and a microporosity, known to enhance bone growth and vascularization. View Full-Text
Keywords: biomaterial; piezoelectric; bone; 3D printing; barium titanate; bioceramic biomaterial; piezoelectric; bone; 3D printing; barium titanate; bioceramic
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MDPI and ACS Style

Polley, C.; Distler, T.; Detsch, R.; Lund, H.; Springer, A.; Boccaccini, A.R.; Seitz, H. 3D Printing of Piezoelectric Barium Titanate-Hydroxyapatite Scaffolds with Interconnected Porosity for Bone Tissue Engineering. Materials 2020, 13, 1773. https://doi.org/10.3390/ma13071773

AMA Style

Polley C, Distler T, Detsch R, Lund H, Springer A, Boccaccini AR, Seitz H. 3D Printing of Piezoelectric Barium Titanate-Hydroxyapatite Scaffolds with Interconnected Porosity for Bone Tissue Engineering. Materials. 2020; 13(7):1773. https://doi.org/10.3390/ma13071773

Chicago/Turabian Style

Polley, Christian, Thomas Distler, Rainer Detsch, Henrik Lund, Armin Springer, Aldo R. Boccaccini, and Hermann Seitz. 2020. "3D Printing of Piezoelectric Barium Titanate-Hydroxyapatite Scaffolds with Interconnected Porosity for Bone Tissue Engineering" Materials 13, no. 7: 1773. https://doi.org/10.3390/ma13071773

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