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Article

Strontium- and Cobalt-Doped Multicomponent Mesoporous Bioactive Glasses (MBGs) for Potential Use in Bone Tissue Engineering Applications

1
Department of Materials Engineering, Faculty of Engineering, Ferdowsi University of Mashhad (FUM), Azadi Sq., Mashhad 917794-8564, Iran
2
Institute of Materials Physics and Engineering, Applied Science and Technology Department, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy
3
Department of Biology, Faculty of Sciences, Islamic Azad University-Mashhad Branch, Mashhad 917794-8564, Iran
4
Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences (IUMS), Tehran 1449614535, Iran
5
Tissue Engineering Research Group (TERG), Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad 917794-8564, Iran
*
Authors to whom correspondence should be addressed.
Materials 2020, 13(6), 1348; https://doi.org/10.3390/ma13061348
Received: 31 December 2019 / Revised: 2 March 2020 / Accepted: 13 March 2020 / Published: 16 March 2020
(This article belongs to the Special Issue Bioactive Ceramics and Glasses 2019)
Mesoporous bioactive glasses (MBGs) offer suitable platforms for drug/ion delivery in tissue engineering strategies. The main goal of this study was to prepare strontium (Sr)- and cobalt (Co)-doped MBGs; strontium is currently used in the treatment of osteoporosis, and cobalt is known to exhibit pro-angiogenic effects. Sr- and Co-doped mesoporous glasses were synthesized for the first time in a multicomponent silicate system via the sol–gel method by using P123 as a structure-directing agent. The glassy state of the Sr- and Co-doped materials was confirmed by XRD before immersion in SBF, while an apatite-like layer was detected onto the surface of samples post-immersion. The textural characteristics of MBGs were confirmed by nitrogen adsorption/desorption measurements. In vitro experiments including MTT assay, Alizarin red staining, and cell attachment and migration showed the cytocompatibility of all the samples as well as their positive effects on osteoblast-like cell line MG-63. Early experiments with human umbilical vein endothelial cells also suggested the potential of these MBGs in the context of angiogenesis. In conclusion, the prepared materials were bioactive, showed the ability to improve osteoblast cell function in vitro and could be considered as valuable delivery vehicles for therapeutics, like Co2+ and Sr2+ ions. View Full-Text
Keywords: biomaterials; bioglass; mesoporous bioactive glass (MBG); ion release; osteogenesis; bone tissue engineering; bioactivity biomaterials; bioglass; mesoporous bioactive glass (MBG); ion release; osteogenesis; bone tissue engineering; bioactivity
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MDPI and ACS Style

Kermani, F.; Mollazadeh Beidokhti, S.; Baino, F.; Gholamzadeh-Virany, Z.; Mozafari, M.; Kargozar, S. Strontium- and Cobalt-Doped Multicomponent Mesoporous Bioactive Glasses (MBGs) for Potential Use in Bone Tissue Engineering Applications. Materials 2020, 13, 1348. https://doi.org/10.3390/ma13061348

AMA Style

Kermani F, Mollazadeh Beidokhti S, Baino F, Gholamzadeh-Virany Z, Mozafari M, Kargozar S. Strontium- and Cobalt-Doped Multicomponent Mesoporous Bioactive Glasses (MBGs) for Potential Use in Bone Tissue Engineering Applications. Materials. 2020; 13(6):1348. https://doi.org/10.3390/ma13061348

Chicago/Turabian Style

Kermani, Farzad, Sahar Mollazadeh Beidokhti, Francesco Baino, Zahra Gholamzadeh-Virany, Masoud Mozafari, and Saeid Kargozar. 2020. "Strontium- and Cobalt-Doped Multicomponent Mesoporous Bioactive Glasses (MBGs) for Potential Use in Bone Tissue Engineering Applications" Materials 13, no. 6: 1348. https://doi.org/10.3390/ma13061348

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